| Neuropathologic correlates for diffusion tensor imaging in postinfectious encephalopathy. | |
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MedLine Citation:
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PMID: 21481751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute necrotizing encephalopathy and acute disseminated encephalomyelitis are 2 rare types of acute postinfectious encephalopathy in children. Acute necrotizing encephalopathy is characterized by multiple symmetric lesions in the thalami, putamena, cerebral and cerebellar white matter, and brainstem. Acute disseminated encephalomyelitis is an immune-mediated demyelinating central nervous system disorder that predominantly affects the white matter. Diffusion magnetic resonance imaging is sensitive to measuring water diffusion in the central nervous system in human and animal models. Recent studies have demonstrated that by using an analytical approach to directional diffusivity-derived parameters, the axial diffusivity and the radial diffusivity, one can assess the extent of axonal or myelin injury in the central nervous system white matter. We applied directional diffusivity to acute necrotizing encephalopathy, acute disseminated encephalomyelitis, and control subjects correlating with neuropathology findings. In acute necrotizing encephalopathy, axonal injury without demyelination, noted on biopsy samples of brain tissue, was suggested by a decreased apparent diffusion coefficient, unchanged fractional anisotropy, and decreased axial and radial diffusivity. In acute disseminated encephalomyelitis, an increased apparent diffusion coefficient, decreased fractional anisotropy, unchanged axial diffusivity, and markedly increased radial diffusivity compatible with active inflammatory demyelination were noted, consistent with tissue biopsy sample neuropathology. In conclusion, diffusion tensor parameters can potentially depict more microstructural changes than conventional magnetic resonance imaging in postinfectious encephalopathy in children. |
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Authors:
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Chin-I Chen; Soe Mar; Stephanie Brown; Sheng-Kwei Song; Tammie L S Benzinger |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric neurology Volume: 44 ISSN: 1873-5150 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-12 Completed Date: 2011-08-04 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 389-93 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anisotropy Brain / pathology* Child Demyelinating Diseases / pathology Diabetes Mellitus, Type 1 / complications Diffusion Tensor Imaging / methods* Humans Image Processing, Computer-Assisted Male Nervous System Diseases / diagnosis*, etiology Neurofilament Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1P01NS059560-01A1/NS/NINDS NIH HHS; P01 AG003991-17/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neurofilament Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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