| The Neuropathies of Waldenström's Macroglobulinemia (WM) and IgM-MGUS. | |
| | |
MedLine Citation:
|
PMID: 21320835 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background: Neuropathy is common in Waldenström's macroglobulinemia (WM, an IgM-associated lymphoplasmacytic lymphoma) and in IgM-monoclonal gammopathy of undetermined significance (IgM-MGUS). Paraneoplastic or paraimmune mechanisms are thought to be involved in the pathogenesis of these neuropathies. Attempts at distinguishing WM and IgM-MGUS neuropathies are lacking especially among bone marrow (BM) confirmed patients. Methods: Retrospective analyses were performed on BM confirmed WM (N=30) and IgM-MGUS (N=73) neuropathy patients with neurologic assessments and hematologic features. Results: The presence of anemia and quantity of IgM monoclonal protein were significantly greater in WM. Based on multiple neurologic assessments differences were not found for: 1) length of time from neurologic symptom onset to evaluation; 2) chief complaint of painless loss of feeling in the feet, Romberg's sign and tremor; and 3) clinical motor, sensory and reflex abnormalities. Autonomic testing was normal in both diseases. Using nerve conduction (NCS) criteria for demyelination, 62% of IgM-MGUS and 27% of WM met this criteria (p=0.013). IgM MGUS patients had greater terminal conduction slowing by ulnar residual latency calculation (<0.01). The degree of axonal loss as measured by summated compound muscle action potentials and available nerve biopsy was not significantly different between diseases. Conclusion: Although WM and IgM-MGUS must be distinguished for hematologic prognosis and treatment, clinical neuropathy presentations of WM and IgM-MGUS are similar and likely related to comparable axonal loss in both conditions. Despite these similarities, evidence of demyelination was found by electrophysiologic studies much more commonly in IgM-MGUS. This difference may reflect varied immune mechanism(s) in the two disorders. |
| | |
Authors:
|
Christopher J Klein; Joon-Shik Moon; Michelle L Mauermann; Steven R Zeldenrust; Yanhong Wu; Angela Dispenzieri; Peter J Dyck |
Related Documents
:
|
19462845 - Impact of supraglottoplasty on aspiration in severe laryngomalacia. 803385 - Necrotizing enterocolitis. 17210495 - Sidestream end-tidal carbon dioxide monitoring during helicopter transport. 16430565 - The effect of gel lubrication on cuff leakage of double lumen tubes during thoracic sur... 3160685 - Use of ipratropium aerosol in the long-term management of asthma. 2426655 - Discrepancy between pit counting and spleen function tests in nutritional anemias and h... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 38 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
|
Languages: eng Pagination: 289-95 Citation Subset: IM |
Affiliation:
|
Peripheral Nerve Research Laboratory, Mayo Clinic, Rochester, Minnesota, U.S.A. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Meaningful change in cognition in multiple sclerosis: method matters.
Next Document: Early Treatment of a Progressive Rasmussen's Like Syndrome with Ganciclovir.