Document Detail


Neuropathic tissue responds preferentially to stimulation by intense focused ultrasound.
MedLine Citation:
PMID:  23200180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the hypothesis that neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue. We created a diffusely neuropathic paw in rats via partial ligation of the sciatic nerve, whose sensitivity to iFU stimulation we compared with sham-surgery and normal control paws. We then applied increasing amounts of iFU (individual 0.2 s pulses at 1.15 MHz) to the rats' paws, assaying for their reliable withdrawal from that stimulation. Neuropathic rats preferentially withdrew their injured paw from iFU at smaller values of iFU intensity (84.2 W/cm(2) ± 25.5) than did sham surgery (97.7 W/cm(2) ± 11.9) and normal control (> 223 W/cm(2)) animals, with greater sensitivity and specificity (85% for neuropathic rats and 50% each of sham surgery and normal control rats). These results directly support our hypothesis as well as Gavrilov's idea that doctors may some day use iFU stimulation to diagnose patients with neuropathies.
Authors:
Rowen E Tych; Michael Gofeld; Jeffrey G Jarvik; Michel Kliot; John D Loeser; Abbi M McClintic; Ryan J Ollos; Kristin D Pederson; Rachel E Sparks; Gregory W Terman; Pierre D Mourad
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  39     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-13     Revised Date:  2014-02-14    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Hindlimb
Hot Temperature
Light
Neuralgia / diagnosis,  physiopathology*
Pain Threshold*
Rats
Rats, Sprague-Dawley
Sciatic Nerve
Ultrasonics*
Grant Support
ID/Acronym/Agency:
R41 NS 049719-01/NS/NINDS NIH HHS; R41 NS049719/NS/NINDS NIH HHS; RR025014/RR/NCRR NIH HHS; UL1 RR025014/RR/NCRR NIH HHS; UL1 TR000423/TR/NCATS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fast and fully automatic 3-d echocardiographic segmentation using B-spline explicit active surfaces:...
Next Document:  The Combined Effects of Hematoporphyrin Monomethyl Ether-SDT and Doxorubicin on the Proliferation of...