Document Detail


Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling.
MedLine Citation:
PMID:  23322114     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pain is an important clinical problem and, in its chronic form, may be a disabling condition. Most currently available therapies are insufficient and/or accompanied by serious side effects. Recent studies have implicated the Ca(V)3.2 isoform of T-type Ca channels in nociceptive signaling. Ca(V)3.2 channels are located in the somas of dorsal root ganglion cells and in the central endings of these cells in the dorsal horn of the spinal cord. These channels can support the development and maintenance of both physiological (nociceptive) and pathological (neuropathic) pain. In this review, we summarize the most recent evidence linking the presynaptic Ca(V)3.2 channels to the etiology of neuropathic pain disorders. In particular, we focus on data linking plasticity of Ca(V)3.2 channels with neuropathic pain disorders associated with mechanical peripheral nerve injury and with diabetic peripheral neuropathy. We also discuss the development of potential pain therapies aimed at these channels.
Authors:
Slobodan M Todorovic; Vesna Jevtovic-Todorovic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Pflugers Archiv : European journal of physiology     Volume:  -     ISSN:  1432-2013     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA, st9d@virginia.edu.
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