Document Detail

Neuronal uptake affects dynamic characteristics of heart rate response to sympathetic stimulation.
MedLine Citation:
PMID:  10409267     Owner:  NLM     Status:  MEDLINE    
Recently, studies in our laboratory involving the use of a Gaussian white noise technique demonstrated that the transfer function from sympathetic stimulation frequency to heart rate (HR) response showed dynamic characteristics of a second-order low-pass filter. However, determinants for the characteristics remain to be established. We examined the effect of an increase in mean sympathetic stimulation frequency and that of a blockade of the neuronal uptake mechanism on the transfer function in anesthetized rabbits. We found that increasing mean sympathetic stimulation frequency from 1 to 4 Hz significantly (P < 0.01) decreased the dynamic gain of the transfer function without affecting other parameters, such as the natural frequency, lag time, or damping coefficient. In contrast, the administration of desipramine (0.3 mg/kg iv), a neuronal uptake blocking agent, significantly (P < 0.01) decreased both the dynamic gain and the natural frequency and prolonged the lag time. These results suggest that the removal rate of norepinephrine at the neuroeffector junction, rather than the amount of available norepinephrine, plays an important role in determining the low-pass filter characteristics of the HR response to sympathetic stimulation.
T Nakahara; T Kawada; M Sugimachi; H Miyano; T Sato; T Shishido; R Yoshimura; H Miyashita; M Inagaki; J Alexander; K Sunagawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  277     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-30     Completed Date:  1999-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R140-6     Citation Subset:  IM    
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan.
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MeSH Terms
Adrenergic Uptake Inhibitors / pharmacology
Desipramine / pharmacology
Electric Stimulation
Heart Rate / physiology*
Sympathetic Nervous System / physiology*
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 50-47-5/Desipramine

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