Document Detail


Neuronal supernumerary and dendritic sprouting of the nucleus ambiguus after chronic alteration of peripheral targets in cats.
MedLine Citation:
PMID:  9733955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anatomic changes of neuronal profiles in response to chronic alteration of peripheral targets were investigated in the nucleus ambiguus (NA) of cats. Unilateral vagal-hypoglossal nerve anastomosis was performed by suturing the transected proximal stump of the vagus nerve to the transected distal stump of the hypoglossal nerve. After comparing horseradish peroxidase (HRP)-labeled neurons on the ipsilateral operated side of the NA with the contralateral unoperated NA and the NA following transection and reuniting to the vagus itself, a remarkable ramification and elongation of the dendritic trees was observed in the HRP-positive neurons on the ipsilateral NA. Quantitative analysis of neuronal profiles revealed that the number of the medium and large neurons on the ipsilateral NA was greater than the contralateral NA and the NA following autologous suturing of the vagus. Comparisons of variable dendritic lengths of the medium and large neurons on the ipsilateral NA revealed longer distances and more branches of the tertiary and perisomatic dendrites than those of the contralateral NA and the NA ipsilateral to autologous reunion. Our results suggest that remarkable sprouting and elongation of the dendritic trees as well as cell supernumerary occurred in the dominant NA motoneurons ipsilateral to the nerve anastomosis. In conclusion, there is a trophic influence in the tongue musculature, which was retrogradely transported to the NA neurons via the regenerating axons and caused the morphological changes in the NA in response to the rerouting of efferents from the vagus nerve to the hypoglossal nerve to innervate intimate tongue musculature.
Authors:
S T Chang; F K Lieu; S D Wang; J C Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  805     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-25     Completed Date:  1998-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  144-54     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Elsevier Science B.V.
Affiliation:
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Cell Count
Dendrites / ultrastructure*
Efferent Pathways / physiology
Female
Horseradish Peroxidase
Hypoglossal Nerve / physiology*
Male
Medulla Oblongata / cytology*,  physiology*,  ultrastructure
Neurons / cytology*
Time Factors
Tongue / physiology
Vagus Nerve / physiology*
Chemical
Reg. No./Substance:
EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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