| Neuronal semaphorins regulate a primary immune response. | |
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MedLine Citation:
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PMID: 17109625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Semaphorins are involved in a wide range of biological processes, including axon guidance, neuronal migration, angiogenesis, cardio- and osteo-genesis. Recently they have also been found to be important for immune response. Sema3A reduces the activation of T cells through its cell-surface receptors, including members of the neuropilin and plexin families. By contrast, Sema4D (CD100), which is expressed on the surface of T, B and dendritic cells, increases B cell and dendritic cell function using either plexin B1 or CD72 as receptors. The transmembrane protein Sema4A is involved in the activation of immune cells through interactions with Tim-2. Emerging evidence also indicates that additional semaphorins and related molecules seem to function in the reciprocal stimulation of T cells and antigen-presenting cells (APCs). This paper discusses the functions of these semaphorins in the immune system, focusing on their roles in T cell-APC interactions. |
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Authors:
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Simona Moretti; Antonio Procopio; Massimo Boemi; Alfonso Catalano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current neurovascular research Volume: 3 ISSN: 1567-2026 ISO Abbreviation: - Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-19 Completed Date: 2007-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208439 Medline TA: Curr Neurovasc Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 295-305 Citation Subset: IM |
Affiliation:
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Department of Molecular Pathology and Innovative Therapies, Marche Polytechnic University, Ancona, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Presenting Cells / immunology Antigens, CD / immunology Humans Immunity, Cellular / immunology* Nervous System / immunology* Neuroimmunomodulation / immunology* Neurons / immunology* Semaphorin-3A / immunology Semaphorins / immunology* T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/CD100 antigen; 0/Semaphorin-3A; 0/Semaphorins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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