| Neuronal regulation of homeostasis by nutrient sensing. | |
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MedLine Citation:
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PMID: 20376051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In type 2 diabetes and obesity, the homeostatic control of glucose and energy balance is impaired, leading to hyperglycemia and hyperphagia. Recent studies indicate that nutrient-sensing mechanisms in the body activate negative-feedback systems to regulate energy and glucose homeostasis through a neuronal network. Direct metabolic signaling within the intestine activates gut-brain and gut-brain-liver axes to regulate energy and glucose homeostasis, respectively. In parallel, direct metabolism of nutrients within the hypothalamus regulates food intake and blood glucose levels. These findings highlight the importance of the central nervous system in mediating the ability of nutrient sensing to maintain homeostasis. Futhermore, they provide a physiological and neuronal framework by which enhancing or restoring nutrient sensing in the intestine and the brain could normalize energy and glucose homeostasis in diabetes and obesity. |
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Authors:
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Tony K T Lam |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature medicine Volume: 16 ISSN: 1546-170X ISO Abbreviation: Nat. Med. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502015 Medline TA: Nat Med Country: United States |
Other Details:
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Languages: eng Pagination: 392-5 Citation Subset: IM |
Affiliation:
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Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada. tony.lam@uhnres.utoronto.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / physiology Brain / physiology Gastrointestinal Tract / injuries*, physiology Homeostasis / physiology* Humans Hypothalamus / physiology Nervous System Physiological Processes / physiology* Nutritional Status / physiology* Rats |
| Grant Support | |
ID/Acronym/Agency:
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86554//Canadian Institutes of Health Research; MOP-82701//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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