Document Detail


Neuronal regulation of bone metabolism and anabolism: calcitonin gene-related peptide-, substance P-, and tyrosine hydroxylase-containing nerves and the bone.
MedLine Citation:
PMID:  12203704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bone alters its metabolic and anabolic activities in response to the variety of systemic and local factors such as hormones and growth factors. Classical observations describing abundance of the nerves fibers in bone also predict a paradigm that the nervous system influences bone metabolism and anabolism. Identification of the nerve-derived signaling molecules, capable of modulating cellular activities of the bone cells, facilitates a novel approach to study the biology of skeletal innervation. Many of the signaling molecules that may act as efferent agents on the bone cells fall into the category of neuropeptides. The present article reviews current understanding of the skeletal innervation and their proposed physiological effects on bone metabolism, with a special interest to calcitonin gene-related peptide (CGRP)-containing nerves fibers. CGRP is abundantly distributed in bone via sensory nerves, especially in the epiphyseal trabecular bones. Its in vitro actions to the cultured osteoblasts and osteoclasts, together with its in vivo localization, strongly support the paradigm that the nervous system influences bone metabolism. In addition, CGRP is recently shown to be expressed endogenously by the osteoblasts. Transgenic mice with osteoblasts overexpressing CGRP are characterized by increased bone formation rate and enhanced bone volume, suggesting that CGRP indeed acts on bone metabolism not only via nervous route but also via autocrine loop. The current article also reviews the distribution of nerve fibers containing substance P (SP), another sensory nerve-specific neuropeptide, and tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine. The distinct effects of SP and catecholamines on the bone cells together with their in vivo influences manifested by experimental denervation studies suggest that the sensory and sympathetic nerves play important roles in bone metabolism.
Authors:
Shinji Imai; Yoshitaka Matsusue
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Microscopy research and technique     Volume:  58     ISSN:  1059-910X     ISO Abbreviation:  Microsc. Res. Tech.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-08-30     Completed Date:  2002-11-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203012     Medline TA:  Microsc Res Tech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-9     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Affiliation:
Department of Orthopeadic Surgery, Shiga University of Medical Science, Setatsukinowa-cho, Otsu-city, 520-2192, Shiga-ken, Japan. simai@belle.shiga-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone and Bones / innervation*,  metabolism,  radiography
Calcitonin / metabolism
Calcitonin Gene-Related Peptide / genetics,  metabolism*
Humans
Models, Biological
Nerve Fibers / physiology*
Substance P / metabolism*
Transgenes
Tyrosine 3-Monooxygenase / metabolism*
Chemical
Reg. No./Substance:
33507-63-0/Substance P; 83652-28-2/Calcitonin Gene-Related Peptide; 9007-12-9/Calcitonin; EC 1.14.16.2/Tyrosine 3-Monooxygenase

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