Document Detail


Neuronal plasticity in memory and learning abilities: theoretical position and selective review.
MedLine Citation:
PMID:  16387375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neural plasticity of modality-nonspecific and modality-specific memory and learning abilities pertains to fluid intelligence and crystallized intelligence, respectively. The limbic system with the novelty neurons of the hippocampus interacts with the prefrontal cortex optimization of the orienting reflex and voluntary attention. Brain-derived neurotrophic factor produced by novelty neurons of the hippocampus contributes to long-term memory formation and improves learning abilities in a wide range of disciplines. Synergistic combination of stimulation with "analytical-specific visual perceptual patterns" and "optimally high" physiological activation of the bilateral electrodermal system optimizes the limbic system and prefrontal cortex activity as demonstrated by enhanced prefrontal N450 ERPs to a memory workload paradigm. This is accompanied by improvements in auditory retention tasks, word memorization, higher school achievement and marks, and an amelioration of "analytical-specific perceptual skills" as measured by the Mangina-Test. Intracerebral ERPs to a memory workload paradigm contributed to the elucidation of limbic structures and neocortical sites involved in memory workload processes. The progressive degeneration of these same structures causes the gradual decline of memory functions observed in early Alzheimer's disease. Research findings indicate that ERPs elicited by a memory workload paradigm are sensitive markers for diagnosis, treatment and clinical follow-up of early Alzheimer's patients. In addition, ERPs provide objective measurement of cholinergic medication effects on cerebral functions involved in memory processes through neuropsychophysiological parameters.
Authors:
Constantine A Mangina; Evgeni N Sokolov
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-01-04
Journal Detail:
Title:  International journal of psychophysiology : official journal of the International Organization of Psychophysiology     Volume:  60     ISSN:  0167-8760     ISO Abbreviation:  Int J Psychophysiol     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-01     Completed Date:  2006-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406214     Medline TA:  Int J Psychophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  203-14     Citation Subset:  IM    
Affiliation:
Montreal Research and Treatment Center for Learning Abilities and Disabilities, Quebec, Canada. mcgill@ca.inter.net
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / cytology*,  physiology
Humans
Intelligence / physiology
Learning / physiology*
Neural Networks (Computer)
Neuronal Plasticity / physiology*
Neurons / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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