| Neuronal nitric oxide synthase and splanchnic blood flow in anaesthetized rats. | |
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MedLine Citation:
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PMID: 15743385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate to what extent the neuronal form of constitutive nitric oxide synthase (nNOS) contributes to the blood perfusion of splanchnic organs, including the islets of Langerhans. METHODS: The nNOS inhibitor 7-nitroindazole (300 mg kg(-1) i.p.) was administered to anaesthetized Sprague-Dawley rats, some of which were pre-treated with the ganglionic blocker hexamethonium (20 mg kg(-1) i.v.) The blood perfusion of the splanchnic organs, including the pancreatic islets was then measured with a microsphere technique. RESULTS: Nitroindazole decreased total pancreatic, duodenal and renal blood flow, whereas pancreatic islet, colonic and adrenal blood flows were unchanged. A slight increase in mean arterial blood pressure was seen after nitroindazole treatment. Nitroindazole did not affect blood glucose or serum insulin concentrations. In separate experiments, hexamethonium affected none of the studied blood flow values, suggesting that the effects of nNOS-inhibition were not mediated from the nervous system. CONCLUSION: Nitric oxide derived from the activity of nNOS contributes to the blood perfusion in the upper portions of the gastrointestinal tract, viz. the parts supplied by the cranial mesenteric artery, and the kidneys, whilst no effects are seen on colonic or adrenal blood flow. Pancreatic islet blood flow was unaffected by nNOS inhibition, thereby suggesting that NO derived from the other isoforms of NOS maintains the high basal islet blood perfusion. |
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Authors:
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L Jansson; P-O Carlsson; B Bodin; A Andersson; O Källskog |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 183 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-03 Completed Date: 2005-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Biomedical Center, Uppsala University, SE 751 23 Uppsala, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General Animals Blood Glucose / metabolism Blood Pressure / drug effects Enzyme Inhibitors / pharmacology Gastrointestinal Tract / blood supply Hexamethonium / pharmacology Indazoles / pharmacology Insulin / blood Islets of Langerhans / blood supply Male Nerve Tissue Proteins / antagonists & inhibitors, physiology* Nitric Oxide Synthase / antagonists & inhibitors, physiology* Nitric Oxide Synthase Type I Rats Rats, Sprague-Dawley Renal Circulation / drug effects, physiology Splanchnic Circulation / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Enzyme Inhibitors; 0/Indazoles; 0/Nerve Tissue Proteins; 11061-68-0/Insulin; 2942-42-9/7-nitroindazole; 60-26-4/Hexamethonium; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type I; EC 1.14.13.39/Nos1 protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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