| Neuronal nitric oxide synthase expression in developing and adult human CNS. | |
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MedLine Citation:
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PMID: 10068309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuronal nitric oxide synthase (nNOS) is constitutively expressed by subpopulations of neurons in the CNS and is involved in neurotransmission, learning and memory, and neuronal injury. While the distribution of nNOS neurons has been characterized in the rodent CNS, the expression in human brain has not been well documented. We determined the expression of nNOS in second trimester human fetal and adult brain. In second trimester fetal brain, the nNOS neurons are concentrated in the developing cerebral cortex at the subplate zone and in layer VI, the striatum, and in certain brainstem nuclei. The nNOS neurons are sparsely distributed in the hippocampus, and virtually absent in the cerebellar cortex. The nNOS neurons in the subplate zone extend their processes radially, suggesting a developmental role, perhaps in guidance. The number and distribution of NADPH diaphorase-positive neurons corresponds to that of the nNOS neurons. While the distribution of nNOS neurons in the adult brain is similar to that found in fetal brain, the overall density is lower in the adult. The highest density of nNOS neurons is found in the striatum followed by the neocortex. A region-specific role for nNOS neurons in human brain and a potential developmental role for nNOS in the cerebral cortex are suggested by these data. |
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Authors:
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M Downen; M L Zhao; P Lee; K M Weidenheim; D W Dickson; S C Lee |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neuropathology and experimental neurology Volume: 58 ISSN: 0022-3069 ISO Abbreviation: J. Neuropathol. Exp. Neurol. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-02-26 Completed Date: 1999-02-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985192R Medline TA: J Neuropathol Exp Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 12-21 Citation Subset: IM |
Affiliation:
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Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / anatomy & histology, physiology* Embryonic and Fetal Development / physiology Female Histocytochemistry Humans Immunohistochemistry Isoenzymes / biosynthesis* Male NADPH Dehydrogenase / metabolism Neurons / enzymology* Nitric Oxide Synthase / biosynthesis* |
| Grant Support | |
ID/Acronym/Agency:
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MH55477/MH/NIMH NIH HHS; RG2771/RG/CSR NIH HHS; TG-NS07098/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.6.99.1/NADPH Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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