Document Detail


Neuronal and molecular substrates for optimal foraging in Caenorhabditis elegans.
MedLine Citation:
PMID:  22135454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Variation in food quality and abundance requires animals to decide whether to stay on a poor food patch or leave in search of better food. An important question in behavioral ecology asks when is it optimal for an animal to leave a food patch it is depleting. Although optimal foraging is central to evolutionary success, the neural and molecular mechanisms underlying it are poorly understood. Here we investigate the neuronal basis for adaptive food-leaving behavior in response to resource depletion in Caenorhabditis elegans, and identify several of the signaling pathways involved. The ASE neurons, previously implicated in salt chemoattraction, promote food-leaving behavior via a cGMP pathway as food becomes limited. High ambient O(2) promotes food-leaving via the O(2)-sensing neurons AQR, PQR, and URX. Ectopic activation of these neurons using channelrhodopsin is sufficient to induce high food-leaving behavior. In contrast, the neuropeptide receptor NPR-1, which regulates social behavior on food, acts in the ASE neurons, the nociceptive ASH neurons, and in the RMG interneuron to repress food-leaving. Finally, we show that neuroendocrine signaling by TGF-β/DAF-7 and neuronal insulin signaling are necessary for adaptive food-leaving behavior. We suggest that animals integrate information about their nutritional state with ambient oxygen and gustatory stimuli to formulate optimal foraging strategies.
Authors:
Kate Milward; Karl Emanuel Busch; Robin Joseph Murphy; Mario de Bono; Birgitta Olofsson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-12-01
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  108     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-21     Completed Date:  2012-03-09     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20672-7     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal
Caenorhabditis elegans / genetics*,  physiology*
Caenorhabditis elegans Proteins / genetics
Carbon Dioxide / chemistry
Chemotaxis
Cyclic GMP / metabolism
Decision Making
Feeding Behavior*
Insulin / metabolism
Neurons / metabolism
Neuropeptides / chemistry
Oxygen / chemistry,  metabolism
Rhodopsin / metabolism
Signal Transduction
Transforming Growth Factor beta / metabolism
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Insulin; 0/Neuropeptides; 0/Transforming Growth Factor beta; 124-38-9/Carbon Dioxide; 7665-99-8/Cyclic GMP; 7782-44-7/Oxygen; 9009-81-8/Rhodopsin
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