Document Detail

Neuronal expression of Fos protein in the paraventricular nucleus of the hypothalamus after i.p. injection of ulcergenic cinchophen.
MedLine Citation:
PMID:  7916144     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to identify the CNS neurons that express Fos protein after i.p. injection of ulcergenic drug cinchophen (300 mg/kg). This was done in unanesthetized Wistar rats with careful physiological controls. The population of Fos-immunoreactive (Fos-ir) neurons was the largest in the medial parvicellular part of the paraventricular nucleus of the hypothalamus (PVH). Distribution of Fos-ir neurons in the PVH corresponds with that of the parvicellular neurons in the PVH which secrete corticotropin-releasing hormone (CRH). This study strongly suggests that the cinchophen-induced peptic ulcer may originate in excitation of the CRH-secreting neurons in the parvicellular part of the PVH.
K Takayama; Y Xiong; M Miura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  172     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-11     Completed Date:  1994-10-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  55-8     Citation Subset:  IM    
Department of Physiology 1st Division, Gunma University School of Medicine, Maebashi-shi, Japan.
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MeSH Terms
Corticotropin-Releasing Hormone / secretion
Injections, Intraperitoneal
Neurons / drug effects,  metabolism*
Paraventricular Hypothalamic Nucleus / cytology,  drug effects,  metabolism*
Proto-Oncogene Proteins c-fos / biosynthesis*,  immunology
Quinolines / administration & dosage,  pharmacology*
Rats, Wistar
Stomach Ulcer / chemically induced
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Quinolines; 9015-71-8/Corticotropin-Releasing Hormone

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