Document Detail

Neuronal changes of hypokalemic myopathy. A light- and electron-microscopic study on muscle biopsy.
MedLine Citation:
PMID:  7354366     Owner:  NLM     Status:  MEDLINE    
Hypokalemic myopathy has been observed in various clinical conditions. There are many studies of the pathomorphological changes of muscle fibers but alterations in intramuscular nerves and motor end-plates are seldom mentioned. The present authors observed biopsied muscle from a 51-year-old housewife who had suffered from gradually increasing muscle weakness. Laboratory examinations revealed a severe hypokalemia of 1.5 mEq/1, 18304 U/1 of CPK, 1300 U/1 of LDH, 343 U/1 of SGOT and 297 IU/1 of adolase. Light-microscopic examination showed changes previously described, including twin-peaked distribution in the histogram of type I, IIA and IIB fibers, ballooning and thickening of terminal axon, and 2 or 3 end-plates closely spaced along the length of muscle fibers. The electron-microscopic examination revealed empty folds of basement membrane in end-plate regions, reduced secondary synaptic clefts, interposition of Schwann cell processes between nerve ending and primary synaptic cleft, and an increase of disarranged microtubules and neurofilaments in terminal axons. The findings suggest that severe hypokalemia primarily produces structural alterations of intramuscular peripheral nerves and motor end-plates as well as of muscle fibers.
S Hashimoto; F Akai; E Semba; K Sakatani; S Hiruma; M Nagaoka; K Hukuda; A Imada
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  44     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-04-23     Completed Date:  1980-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  169-79     Citation Subset:  IM    
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MeSH Terms
Axons / ultrastructure
Cytoplasm / ultrastructure
Hypokalemia / complications*,  pathology
Microscopy, Electron
Microtubules / ultrastructure
Middle Aged
Mitochondria, Muscle / ultrastructure
Muscles / pathology*
Muscular Diseases / pathology*
Myofibrils / ultrastructure
Neuromuscular Junction / ultrastructure
Sarcoplasmic Reticulum / ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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