| Neuronal caspase-3 signaling: not only cell death. | |
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MedLine Citation:
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PMID: 19960023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caspases are a family of cysteinyl aspartate-specific proteases that are highly conserved in multicellular organisms and function as central regulators of apoptosis. A member of this family, caspase-3, has been identified as a key mediator of apoptosis in neuronal cells. Recent studies in snail, fly and rat suggest that caspase-3 also functions as a regulatory molecule in neurogenesis and synaptic activity. In this study, in addition to providing an overview of the mechanism of caspase-3 activation, we review genetic and pharmacological studies of apoptotic and nonapoptotic functions of caspase-3 and discuss the regulatory mechanism of caspase-3 for executing nonapoptotic functions in the central nervous system. Knowledge of biochemical pathway(s) for nonapoptotic activation and modulation of caspase-3 has potential implications for the understanding of synaptic failure in the pathophysiology of neurological disorders. Fine-tuning of caspase-3 lays down a new challenge in identifying pharmacological avenues for treatment of many neurological disorders. |
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Authors:
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M D'Amelio; V Cavallucci; F Cecconi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-12-04 |
Journal Detail:
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Title: Cell death and differentiation Volume: 17 ISSN: 1476-5403 ISO Abbreviation: Cell Death Differ. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-27 Revised Date: 2011-11-24 |
Medline Journal Info:
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Nlm Unique ID: 9437445 Medline TA: Cell Death Differ Country: England |
Other Details:
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Languages: eng Pagination: 1104-14 Citation Subset: IM |
Affiliation:
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Dulbecco Telethon Institute, Department of Biology, University of Rome Tor Vergata, Rome, Italy. m.damelio@hsantalucia.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Caspase 3 / genetics, metabolism*, physiology Gene Knockout Techniques Mice Nervous System Diseases / etiology Neuronal Plasticity / physiology Neurons / cytology, enzymology* Rats Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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TCR04004//Telethon |
| Chemical | |
Reg. No./Substance:
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EC 3.4.22.-/Caspase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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