Document Detail


Neuronal asymmetries in primary visual cortex of dyslexic and nondyslexic brains.
MedLine Citation:
PMID:  10443884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dyslexic brains exhibit histologic changes in the magnocellular (magno) cells of the lateral geniculate nucleus, and consistent with these changes, dyslexics demonstrate abnormal visually evoked potentials and brain activation to magno-specific stimuli. The current study was aimed at determining whether these findings were associated with changes in the primary visual cortex with the prediction that magno components of this cortex would be affected. We measured cross-sectional neuronal areas in primary visual cortex (area 17) in dyslexic and nondyslexic autopsy specimens. There was a significant interaction between hemispheres and diagnostic category; ie, nondyslexic brains had larger neurons in the left hemisphere, whereas dyslexic brains had no asymmetry. On the other hand, cell layers associated with magno input from the lateral geniculate nucleus did not show consistent changes in dyslexic brains. Thus, there is a neuronal size asymmetry in favor of the left primary visual cortex in nondyslexics that is absent in dyslexic brains. This is yet another example of anomalous expression of cerebral asymmetry in dyslexia similar to that of the planum temporale, which in our view reflects abnormality in circuits involved in reading.
Authors:
A R Jenner; G D Rosen; A M Galaburda
Related Documents :
18057074 - Unravelling boléro: progressive aphasia, transmodal creativity and the right posterior ...
16167324 - Sex-specific alterations of cerebral cortical cell size in rats exposed prenatally to d...
18644454 - Neural correlates of hemispheric dominance and ipsilaterality within the vestibular sys...
2811674 - Categorization versus distance: hemispheric differences for processing spatial informat...
10719354 - Developmental dynamics of peripheral glia in drosophila melanogaster.
21490794 - Prenatal brain damage in preeclamptic animal model induced by gestational nitric oxide ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  46     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-31     Completed Date:  1999-08-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-96     Citation Subset:  IM    
Affiliation:
Dyslexia Research Laboratory and Charles A. Dana Research Institute, and Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Dyslexia / pathology*
Female
Functional Laterality
Humans
Male
Middle Aged
Neurons / pathology
Visual Cortex / pathology*
Grant Support
ID/Acronym/Agency:
HD 20806/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Which glioblastoma multiforme patient will become a long-term survivor? A population-based study.
Next Document:  Magnetic resonance imaging results of the PRISMS trial: a randomized, double-blind, placebo-controll...