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Neuronal apoptosis in the neonates born to preeclamptic mothers.
MedLine Citation:
PMID:  23356530     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT Objective: Preeclampsia may result in uteroplacental insufficiency and chronic intrauterine fetal distress. The aim of this study is to address this issue investigating neuronal apoptosis in an experimental model of preeclampsia and to evaluate the neurological outcome of the perinatal asphyxia in the neonates born to preeclamptic mother. Material and Methods: Two of four pregnant Sprague-Dawley rats (preeclamptic group) were given water containing 1.8% NaCl on gestation day 15 and 22 in order to establish the model of preeclampsia whereas other two (non-preeclamptic group) received normal diet. A model of perinatal asphyxia was established on the postnatal 7th day to one preeclamptic and one non-preeclamptic dam. Overall 23 pups born to overall four dams were decapitated to assess neuronal apoptosis by the TUNEL assay. Results: The number of apoptotic neuronal cells was significantly higher in the preeclampsia groups in comparison with the control group (p=0.006 and p=0.006, respectively). It was also significantly higher in the asphyctic/non-preeclamptic group than the count in the control group (p=0.01). There was also significant difference between both asphyctic groups (p=0.003). Conclusion: We conclude that preeclampsia causes small babies for the gestational age and cerebral hypoplasia. Both preeclampsia and perinatal asphyxia can cause increased neuronal apoptosis in the neonatal brains. However the prognosis for neurological outcome is much worse when the perinatal asphyxia occurs in newborns born to preeclamptic mothers.
Authors:
Hese Cosar; Erdener Ozer; Hande Topel; Zelal Kahramaner; Ebru Turkoglu; Aydin Erdemir; Sumer Sutcuoglu; Alper Bagriyanik; Esra Arun Ozer
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Tepecik Training and Research Hospital, Neonatology Clinic, Yenisehir, Izmir, Turkey.
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