Document Detail


Neuronal Differentiation of Human Mesenchymal Stromal Cells Increases their Resistance to Aβ42 Aggregate Toxicity.
MedLine Citation:
PMID:  21876252     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cell therapy is a promising approach for the treatment of neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. However, the presence of toxic aggregates in tissue raises the question of whether grafted stem cells are susceptible to amyloid toxicity before they differentiate into mature neurons. To address this question, we investigated the relative vulnerability of human mesenchymal stromal cells and their neuronally differentiated counterparts to Aβ42 oligomers and whether susceptibility correlates with membrane GM1 content, a key player in oligomer toxicity. We found that our cell model was highly susceptible to aggregate toxicity, whereas neuronal differentiation induced resistance to amyloid species. This data correlated well with the content of membrane GM1, levels of which decreased considerably in differentiated cells. These findings extend our knowledge of stem cell vulnerability to amyloid species, which remains a controversial issue, and confirm that amyloid-GM1 interactions play an important role in cell impairment.
Authors:
Cristina Cecchi; Elisa Evangelisti; Roberta Cascella; Mariagioia Zampagni; Susanna Benvenuti; Paola Luciani; Cristiana Deledda; Ilaria Cellai; Daniel Wright; Riccardo Saccardi; Alessandro Peri; Massimo Stefani
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-26
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  -     ISSN:  1875-8908     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Biochemical Sciences, and Research Centre on the Molecular Basis of Neurodegeneration (CIMN), Florence, Italy.
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