Document Detail


Neuron-specific enolase in non-neoplastic lung diseases, a marker of hypoxemia?
MedLine Citation:
PMID:  10079389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuron-specific enolase (NSE) is a glycolytic enzyme localized within neuronal and neuroendocrine tissues. Serum NSE is widely used as a marker of neuroendocrine tumors. Moderate serum NSE elevation has been reported in some patients with benign lung diseases. We decided to investigate whether the elevation of serum NSE in non-neoplastic lung diseases is connected with hypoxemia and to what extent the recovery of sufficient ventilation with a respirator may influence NSE concentrations. Serum NSE was estimated by means of radioimmunoassay in 83 patients with various non-neoplastic lung diseases. Serum NSE exceeding 12.5 micrograms/L was significantly more frequent in patients with marked hypoxemia (PaO2 < 6.67 kPa; p = 0.03) than in others. The median NSE value in the group of patients without respiratory failure (Ro) was 7.2 micrograms/L (10% > 12.5 micrograms/L), in the group of patients with respiratory failure not requiring mechanical ventilation (Rf) it was 8.5 micrograms/L (24% > 12.5 micrograms/L), and in the group of patients with respiratory failure requiring mechanical ventilation (Rfv) 13.1 micrograms/L (60% > 12.5 micrograms/L). The differences between the Rfv group and the other two groups (Rf and Ro) were significant (P = 0.049 and p = 0.0004, respectively). During successful mechanical ventilation elevated serum NSE decreased to values below the cutoff in 8/10 patients. We conclude that serum NSE elevation is a frequent event in patients with terminal hypoxemia in the course of benign lung diseases. Normalization of serum NSE is observed in the majority of patients during the first week of mechanical ventilation.
Authors:
M Szturmowicz; J Burakowski; W Tomkowski; A Sakowicz; S Filipecki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of biological markers     Volume:  13     ISSN:  0393-6155     ISO Abbreviation:  Int. J. Biol. Markers     Publication Date:    1998 Jul-Sep
Date Detail:
Created Date:  1999-05-24     Completed Date:  1999-05-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8712411     Medline TA:  Int J Biol Markers     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  150-3     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anoxia / complications,  diagnosis*
Blood Gas Analysis
Female
Humans
Lung Diseases / blood*,  complications
Male
Middle Aged
Phosphopyruvate Hydratase / blood*
Respiratory Function Tests
Chemical
Reg. No./Substance:
EC 4.2.1.11/Phosphopyruvate Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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