Document Detail


Neuron specific enolase, carcinoembryonic antigen and lactate dehydrogenase as indicators of disease activity in small cell lung cancer.
MedLine Citation:
PMID:  2537729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical value of the three serum biomarkers neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and lactate dehydrogenase (LDH) were evaluated prospectively in 86 patients with small cell lung cancer (SCLC) entered into randomized clinical trials. The patients were monitored clinically very closely and biomarkers were measured before each course of chemotherapy. The correlation between disease extent and biomarker was significant for both NSE (2P: 0.001) and LDH (2P:0.05). Of those two biomarkers NSE was the most sensitive and was raised in 75% of all patients at diagnosis, in 67% of patients with limited disease, and in 86% of patients with extensive disease. All patients with three or more sites involved presented raised serum NSE levels but there was no significant correlation between definite number or specific sites known to have metastatic disease. There was a tendency towards a higher serum CEA level in extensive disease than in local disease. Only half the patients with metastatic disease had elevated (greater than 5.0 ng/ml) levels of CEA, and values above 50.0 ng/ml were unusual. In patients initially seropositive for NSE a close correlation was found during follow up between serum NSE and response (98%) or progressive systemic disease (100%). During a major response, either complete or partial, serum NSE showed minor fluctuations (mean 8 ng/ml, S.D. 1.79, range 4.6-12.1). At present serum NSE seem to be the most sensitive and valuable biomarker in the management of SCLC, while the gain by adding CEA is small. Furthermore, NSE may be a useful tool in the estimation of disease extent and response to treatment in patients in whom clinical or radiological evaluation is difficult.
Authors:
L G Jørgensen; H H Hansen; E H Cooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer & clinical oncology     Volume:  25     ISSN:  0277-5379     ISO Abbreviation:  Eur J Cancer Clin Oncol     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-04-19     Completed Date:  1989-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112045     Medline TA:  Eur J Cancer Clin Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Affiliation:
Department of Oncology ONB, Finsen Institute, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoembryonic Antigen / metabolism
Carcinoma, Small Cell / drug therapy,  enzymology*
Female
Humans
L-Lactate Dehydrogenase / blood
Lung Neoplasms / drug therapy,  enzymology*
Male
Middle Aged
Neoplasm Metastasis
Phosphopyruvate Hydratase / blood
Prospective Studies
Tumor Markers, Biological / blood
Chemical
Reg. No./Substance:
0/Carcinoembryonic Antigen; 0/Tumor Markers, Biological; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 4.2.1.11/Phosphopyruvate Hydratase

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