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Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA.
MedLine Citation:
PMID:  21151668     Owner:  NLM     Status:  In-Data-Review    
This study evaluates the proliferative effects of danshen and its monomer extract, tanshinone IIA, on Schwann cell proliferation. A piece of silicone rubber was guided across a 15-mm gap in the sciatic nerve of a rat. This nerve gap was then filled with different concentrations of danshen (0-100 mg/mL). The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner. RSC96, Schwann cells were also administered with danshen (0, 20, 40, 60, 80, and 100 μg/mL) and tanshinone IIA (0, 2, 4, 6, 8, and 10 μg/mL). In lower concentrations, danshen and tanshinone IIA exhibited an apparent effect on Schwann cells. Similar effects were also demonstrated in the FGF-2-uPA regulating cascade and cell cycle proliferative protein results. Schwann cell migration was elevated as well. We used MAPK-signaling chemical inhibitors and identified the proliferative effects of danshen and tanshinone IIA as MAPK-signaling dependent. The results from the in vitro systems indicate that danshen and tanshinone IIA can be used to induce Schwann cell proliferation, and in vivo results potentially suggest that danshen and tanshinone IIA might enhance neuron regeneration.
Jui-Lung Shen; Yueh-Sheng Chen; Jing-Ying Lin; Yun-Chen Tien; Wen-Huang Peng; Chia-Hua Kuo; Bor-Show Tzang; Hwai-Lee Wang; Fuu-Jen Tsai; Ming-Chih Chou; Chih-Yang Huang; Chien-Chung Lin
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Publication Detail:
Type:  Journal Article     Date:  2010-12-01
Journal Detail:
Title:  Evidence-based complementary and alternative medicine : eCAM     Volume:  2011     ISSN:  1741-4288     ISO Abbreviation:  Evid Based Complement Alternat Med     Publication Date:  2011  
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101215021     Medline TA:  Evid Based Complement Alternat Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  378907     Citation Subset:  -    
Department of Dermatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
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