| [Neuromyelitis optica spectrum disorder: a case report]. | |
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MedLine Citation:
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PMID: 22466233 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Neuromyelitis optica (NMO) is a relapsing inflammatory disease of the central nervous system, usually affecting the optic nerves and the spinal cord. It is presumed to be an antibody-mediated disorder and the target antigen is the water channel aquaporin-4 (AQP4) on astrocyte cell membranes. NMO is a disease caused by astrocyte disorder and is distinct from multiple sclerosis (MS), which is a primarily demyelinating disease caused by oligodendrocyte disorder. In NMO, spinal MRI shows a T2-hyperintense, longitudinally extensive (≧3 vertebral segments) spinal cord lesion. The case, which has optic neuritis or transverse myelitis with the presence of AQP4 antibody, is called as NMO spectrum disorder. A 68 year-old woman with a history of hypertension and diabetes mellitus was brought to the former hospital by ambulance with acute onset of tetraparesis. She denied visual acuity disturbance. MRI revealed a T2-hyperintense lesion from C5 to T2 level. Laboratory examination showed the presence of AQP4 antibody and the absence of oligoclonal bands. Low-dose steroid treatment was started after establishing a diagnosis of NMO. She incompletely recovered from disability, although the T2-hyperintense lesion on MRI had almost disappeared six months after the onset. It is important to maintain a high index of suspicion for NMO in cases with a longitudinally extensive spinal cord lesion, because untreated NMO leads to severe disability. |
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Authors:
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Tetsuryu Mitsuyama; Taku Yoneyama; Sakiko Suzuki; Mizuo Kagawa; Takakazu Kawamata |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: No shinkei geka. Neurological surgery Volume: 40 ISSN: 0301-2603 ISO Abbreviation: No Shinkei Geka Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0377015 Medline TA: No Shinkei Geka Country: Japan |
Other Details:
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Languages: jpn Pagination: 337-42 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Tokyo Women's Medical University Yachiyo Medical Center. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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