Document Detail

Neuromyelitis optica: a separate disease entity associated with aquaporin-4-antibodies
MedLine Citation:
PMID:  18189220     Owner:  NLM     Status:  MEDLINE    
Neuromyelitis optica (NMO; Devic's Syndrome) is an idiopathic, often relapsing, severe inflammatory disorder preferentially affecting optic nerves and spinal cord. The distinction of NMO from multiple sclerosis (MS) as a separate disease entity has been controversally discussed for a long time. Though both diseases show demyelinisation, they differ in typical clinical, imaging and immunopathological findings. The recent identification of serum aquaporin (AQP)-4 antibody clearly separates NMO from MS. In addition, the identification of AQP-4 antibodies supports peripheral humoral autoimmune pathogenesis in NMO and permits early initiation of effective therapy for prevention of attack-related disability.
B Jordan; K Eger; M E Kornhuber; S Zierz
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Fortschritte der Neurologie-Psychiatrie     Volume:  76     ISSN:  0720-4299     ISO Abbreviation:  Fortschr Neurol Psychiatr     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8103137     Medline TA:  Fortschr Neurol Psychiatr     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  21-7     Citation Subset:  IM    
Klinik und Poliklinik für Neurologie, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale.
Vernacular Title:
Neuromyelitis optica: eine mit Aquaporin-4-Antikörpern assoziierte nosologische Entität.
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MeSH Terms
Aquaporin 4 / immunology*
Autoantibodies / immunology*
Diagnosis, Differential
Neuromyelitis Optica / cerebrospinal fluid,  diagnosis,  epidemiology,  immunology*,  pathology,  physiopathology,  therapy
Reg. No./Substance:
0/Aquaporin 4; 0/Autoantibodies

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