Document Detail

Neuromyelitis optica in patients with myasthenia gravis who underwent thymectomy.
MedLine Citation:
PMID:  16769866     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Myasthenia gravis (MG) and neuromyelitis optica (NMO, also known as Devic disease) are rare autoimmune disorders, with upper-limit prevalence estimates in the general population of 15 per 100,000 and 5 per 100,000, respectively. To our knowledge, an association between these diseases has not been previously reported. OBJECTIVES: To describe 4 patients with MG who developed NMO after thymectomy and to analyze possible causes of apparent increased prevalence of NMO among patients with MG. DESIGN: Case series. PATIENTS: Four patients with MG who underwent thymectomy. INTERVENTIONS: None. RESULTS: The prevalence of MG within the published cohort of patients with NMO is more than 150 times higher than that in the general population. CONCLUSION: Dysregulation of B-cell autoimmunity in myasthenia, possibly exacerbated by loss of control over autoreactive cells as a result of thymectomy, may predispose patients to the development of NMO.
Ilya Kister; Sandeep Gulati; Cavit Boz; Roberto Bergamaschi; Giovanni Piccolo; Guiseppe Piccolo; Joel Oger; Michael L Swerdlow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  63     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-07-26     Revised Date:  2006-09-21    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  851-6     Citation Subset:  AIM; IM    
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
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MeSH Terms
Magnetic Resonance Imaging
Myasthenia Gravis / complications,  pathology,  surgery*
Neuromyelitis Optica / complications,  pathology,  surgery*
Thymectomy / methods*
Treatment Outcome
Erratum In:
Arch Neurol. 2006 Sep;63(9):1342
Note: Piccolo, Guiseppe [corrected to Piccolo, Giovanni]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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