Document Detail


Neuromyelitis optica in a patient with pemphigus foliaceus.
MedLine Citation:
PMID:  22632778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuromyelitis optica (NMO, also eponymously known as Devic's disease) is an immune-mediated demyelinating disease of the central nervous system that can lead to significant disability. Pediatric NMO is a rare disorder often reported after an infection. The authors report a 16 year-old female patient with pemphigus foliaceus who developed subacute optic neuritis followed by cervical transverse myelitis. Restricted distribution of the lesions in the optic nerve and spinal cord was confirmed by ophthalmological evaluation and magnetic resonance imaging of the brain and spinal cord. She was started on intravenous methylprednisolone and then given a maintenance oral prednisone. Subsequently, she was treated with a nonsteroidal immunosuppressant, mycophenolate mofetil, with a target dose of 1000 mg twice a day. Over the course of months, patient noted significant recovery of previous deficits and resolution of the cervical cord enhancement, expansion and cystic dilatation that was previously seen. This case is noteworthy for being the first patient reported with neuromyelitis optica associated with pemphigus foliaceus.
Authors:
R Salazar; M Cerghet; E Farhat; H W Lim
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-05-24
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  319     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-06-20     Completed Date:  2013-02-12     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  152-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA. ricsalmont@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain / pathology*
Female
Humans
Immunosuppressive Agents / therapeutic use
Methylprednisolone / therapeutic use
Mycophenolic Acid / analogs & derivatives,  therapeutic use
Neuromyelitis Optica / complications*,  drug therapy,  pathology
Optic Nerve / pathology
Pemphigus / complications*,  drug therapy,  pathology
Spinal Cord / pathology*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 83-43-2/Methylprednisolone; 9242ECW6R0/mycophenolate mofetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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