Document Detail


Neuromyelitis optica: clinical manifestations and neuroimaging features.
MedLine Citation:
PMID:  23186898     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system with distinguishing features from multiple sclerosis. Understanding of clinical presentation, immunopathology, and imaging features has changed during the last decade. The identification of NMO immunoglobulin G and aquaporin 4 as the target antigen in this disease helped to define the NMO spectrum of disorders and showed that NMO is an autoimmune channelopathy of the central nervous system. Several types of brain involvement have been described in patients with NMO. This article discusses the epidemiology, clinical manifestations, and immunopathogenesis of the disease with an emphasis on neuroimaging.
Authors:
Mohammad Ali Sahraian; Ernst-Wilhelm Radue; Alireza Minagar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologic clinics     Volume:  31     ISSN:  1557-9875     ISO Abbreviation:  Neurol Clin     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8219232     Medline TA:  Neurol Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2013. Published by Elsevier Inc.
Affiliation:
Sina MS Research Center, Iranian Center for Neurological Research, Sina Hospital, Hassan abad Square, Tehran, Iran. Electronic address: msahrai@sina.tums.ac.ir.
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