| Neuromyelitis optica: a case report. | |
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MedLine Citation:
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PMID: 21146800 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Neuromyelitis optica (NMO, Devic's syndrome) is a demyelinating disease of the central nervous system that predominantly affects the spinal cord and optic nerves. It is often confused with multiple sclerosis. Early discrimination between NMO and multiple sclerosis is important because the two diseases have different natural histories and treatment regimens. Seropositivity for NMO-IgG and longitudinally extensive spinal cord lesions (3 or more spinal segments) are characteristic of NMO. Despite the absence of a definitive therapeutic strategy for NMO syndrome, methylprednisolone pulse therapy is recommended in the acute phase. Treatment strategies in relapse phases are aimed at preventing relapses, and increasing evidence shows a better clinical response of immunosuppressive therapy than immuno-modulating therapy (a standard multiple sclerosis-modulating therapy). We describe a 10-year-old girl who had visual loss due to acute optic neuritis at 6 years old and suffered repetitive myelitis 2 years later. NMO was diagnosed because of characteristic longitudinal myelitis and positive NMO-IgG. After combining therapy with prednisolone and an immunosuppressant (cyclophosphamide), the patient's medical condition was stable and no relapse symptoms were observed. |
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Authors:
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Wei-Chia Chia; Jian-Nan Wang; Ming-Chi Lai |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics and neonatology Volume: 51 ISSN: 1875-9572 ISO Abbreviation: Pediatr Neonatol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101484755 Medline TA: Pediatr Neonatol Country: Singapore |
Other Details:
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Languages: eng Pagination: 347-52 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Family Medicine, Chi-Mei Medical Center, Yong Kang Campus, 901 Chung Hwa Road, Tainan, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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