Document Detail


Neuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese.
MedLine Citation:
PMID:  19138340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients. METHODS: Neuromyelitis optica-IgG was detected by indirect immunofluorescence using primate cerebellum. RESULTS: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG seropositive (n = 12) with NMO-IgG seronegative (n = 8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P = 0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. CONCLUSION: Neuromyelitis optica -IgG facilitates diagnosis of NMO spectrum disorders. NMO-IgG seropositivity is associated with higher relapse rate in first 2 years.
Authors:
K H Chan; D B Ramsden; Y L Yu; K H H Kwok; A C Y Chu; P W L Ho; J S C Kwan; R Lee; E Lim; M H W Kung; S L Ho
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  16     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-14     Completed Date:  2009-07-09     Revised Date:  2009-07-10    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  310-6     Citation Subset:  IM    
Affiliation:
University Department of Medicine, Research Center for Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. koonho@hkucc.hku.hk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aquaporin 4 / immunology
Autoantibodies / blood*
Autoimmune Diseases of the Nervous System / immunology*
Demyelinating Diseases / immunology*
Female
Fluorescent Antibody Technique, Indirect
Humans
Immunoglobulin G / blood*
Logistic Models
Male
Middle Aged
Multiple Sclerosis / immunology
Myelitis, Transverse / immunology
Neuromyelitis Optica / immunology*
Optic Neuritis / immunology
Recurrence
Young Adult
Chemical
Reg. No./Substance:
0/AQP4 protein, human; 0/Aquaporin 4; 0/Autoantibodies; 0/Immunoglobulin G
Comments/Corrections
Comment In:
Eur J Neurol. 2009 Apr;16(4):433-5   [PMID:  19348617 ]

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