| Neuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese. | |
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MedLine Citation:
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PMID: 19138340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients. METHODS: Neuromyelitis optica-IgG was detected by indirect immunofluorescence using primate cerebellum. RESULTS: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG seropositive (n = 12) with NMO-IgG seronegative (n = 8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P = 0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. CONCLUSION: Neuromyelitis optica -IgG facilitates diagnosis of NMO spectrum disorders. NMO-IgG seropositivity is associated with higher relapse rate in first 2 years. |
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Authors:
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K H Chan; D B Ramsden; Y L Yu; K H H Kwok; A C Y Chu; P W L Ho; J S C Kwan; R Lee; E Lim; M H W Kung; S L Ho |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 16 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-04-14 Completed Date: 2009-07-09 Revised Date: 2009-07-10 |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 310-6 Citation Subset: IM |
Affiliation:
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University Department of Medicine, Research Center for Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. koonho@hkucc.hku.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aquaporin 4 / immunology Autoantibodies / blood* Autoimmune Diseases of the Nervous System / immunology* Demyelinating Diseases / immunology* Female Fluorescent Antibody Technique, Indirect Humans Immunoglobulin G / blood* Logistic Models Male Middle Aged Multiple Sclerosis / immunology Myelitis, Transverse / immunology Neuromyelitis Optica / immunology* Optic Neuritis / immunology Recurrence Young Adult |
| Chemical | |
Reg. No./Substance:
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0/AQP4 protein, human; 0/Aquaporin 4; 0/Autoantibodies; 0/Immunoglobulin G |
| Comments/Corrections | |
Comment In:
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Eur J Neurol. 2009 Apr;16(4):433-5
[PMID:
19348617
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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