Document Detail


Neuromyelitis optica: Concepts in evolution.
MedLine Citation:
PMID:  21067820     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Neuromyelitis optica (NMO) is a rare demyelinating disease, affecting selectively the optic nerve and the spinal cord. It was previously considered to be a severe variant of multiple sclerosis (MS) due to the similar pathological features and its resemblance to optico-spinal, or Japanese, MS, typical of Asian populations. The finding that most NMO patients have auto-antibodies against aquaporin-4, a water channel particularly abundant on the astrocytes of the glia limitans, has allowed early diagnosis and specific treatment of these patients, and has greatly improved our knowledge of its pathogenesis. When laboratories worldwide can detect anti-aquaporin-4 auto-antibodies with comparable sensitivity and specificity, we will be able to have large multi-centric studies to define better the epidemiological, clinical and pathological features of patients and their responses to treatment.
Authors:
Raffaella Fazio; Marta Radaelli; Roberto Furlan
Publication Detail:
Type:  Journal Article     Date:  2010-11-09
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  231     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  100-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
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