Document Detail


Neuromuscular transmission failure and muscle fatigue in ankle muscles of the adult rat after spinal cord injury.
MedLine Citation:
PMID:  19644032     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Current evidence suggests that significant morphological changes occur in nerve-muscle connections caudal to spinal cord injury (SCI). To determine whether neuromuscular junction (NMJ) function is compromised after SCI, we investigated the contribution of NMJ failure to hindlimb muscle fatigue in control and spinalized adult rats. Repetitive supramaximal nerve stimulation was applied to two muscle-nerve preparations: medial gastrocnemius (MG)-tibial and tibialis anterior (TA)-peroneal. NMJ transmission failure was evident in control and SCI animals after repetitive stimulation. At 2 wk post-SCI, NMJ transmission failure was greater in SCI animals compared with controls, but the difference was not significant (P = 0.205 for the MG and P = 0.053 for the TA). At 6 wk post-SCI, there was a significant but small difference in NMJ transmission failure for the TA between control and spinal animals. These results demonstrate that, although there may be a mild decrement in NMJ function, NMJ transmission remains largely intact for supramaximal nerve stimulation.
Authors:
Karen Ollivier-Lanvin; Michel A Lemay; Alan Tessler; Anthony S Burns
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-07-30
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  107     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2009-12-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1190-4     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Anatomy, Drexel Univ. College of Medicine, 2900 W. Queen Lane, Philadelphia, PA 19129, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Electric Stimulation
Female
Muscle Fatigue*
Muscle Strength
Muscle, Skeletal / innervation,  physiopathology*
Neuromuscular Junction / physiopathology*
Peroneal Nerve / physiopathology
Rats
Rats, Sprague-Dawley
Spinal Cord Injuries / physiopathology*
Synaptic Transmission*
Tarsus, Animal
Tibial Nerve / physiopathology
Time Factors
Grant Support
ID/Acronym/Agency:
1-KO8-HD-052619/HD/NICHD NIH HHS; 5-K25-NS-41975/NS/NINDS NIH HHS; NS-007440/NS/NINDS NIH HHS; P01-NS-055976/NS/NINDS NIH HHS
Comments/Corrections

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