| Neuromuscular monitoring at the orbicularis oculi may overestimate the blockade in myasthenic patients. | |
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MedLine Citation:
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PMID: 11046205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In most publications about myasthenia, monitoring neuromuscular blockade during anesthesia is recommended. In healthy patients, the relation of blockade between muscles has been established, but there is little information about the relation in myasthenic patients. Our objective was to investigate whether the relation between the orbicularis oculi and adductor pollicis muscles is the same in healthy patients and myasthenic patients. METHODS: After anesthesia was induced with 4-6 mg/kg thiopental and 2 microg/kg fentanyl, followed by 2% sevoflurane and 60% nitrous oxide in oxygen, 10 healthy patients and 10 myasthenic patients received 0. 025 and 0.01 mg/kg vecuronium, respectively. Neuromuscular monitoring was performed with use of accelerometry at the orbicularis oculi and the adductor pollicis muscles by stimulating the temporal branch of the facial nerve and the ulnar nerve. RESULTS: The relation of blockade between these two muscles was not the same in healthy patients and myasthenic patients: in healthy patients, the maximum neuromuscular blockade with 0.025 mg/kg vecuronium was less in the orbicularis oculi than in the adductor pollicis (median 72% vs. 91%; P < 0.05); in contrast, in myasthenic patients, the blockade with 0.01 mg/kg vecuronium was greater in the orbicularis oculi than in the adductor pollicis (median 96% vs. 62%; P < 0.05). CONCLUSION: Neuromuscular monitoring at the orbicularis oculi may overestimate blockade in myasthenic patients. Extubation must be performed when the muscle most sensitive to neuromuscular blocking agents is recovered. Therefore, neuromuscular monitoring at the orbicularis oculi is recommended to avoid persistent neuromuscular blockade in patients with myasthenia gravis. |
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Authors:
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H Itoh; K Shibata; M Yoshida; K Yamamoto |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Anesthesiology Volume: 93 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-14 Completed Date: 2000-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1194-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Kanazawa University, Kanazawa, Japan. hironori@med.kanazawa-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anesthesia, General / methods Electromyography / methods Facial Nerve / drug effects, physiopathology Female Humans Male Middle Aged Monitoring, Intraoperative / methods Muscle, Skeletal / drug effects, innervation, physiology Myasthenia Gravis / physiopathology* Neuromuscular Blockade* Neuromuscular Nondepolarizing Agents / therapeutic use Oculomotor Muscles / drug effects*, innervation, physiopathology* Ulnar Nerve / drug effects, physiopathology Vecuronium Bromide / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Neuromuscular Nondepolarizing Agents; 50700-72-6/Vecuronium Bromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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