| Neuromuscular frequency-coding and fatigue. | |
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MedLine Citation:
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PMID: 8585446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In daily life, muscle fatigue often becomes noticeable as an apparent decline in the efficiency of force production by central commands, making it necessary to increase drive (or "effort") to produce a constant motor output. Such aspects of fatigue may be caused by changes in the way in which synaptic messages arriving at the motoneurons are translated into forces by the muscle fibers. Therefore, an understanding of these neuromuscular gradation mechanisms is essential for any analysis of motor fatigue. A brief general review is given of 1) how muscle fibers transduce motoneuronal discharge rates into force; 2) how synaptic currents are transduced into motoneuronal discharge rates; 3) how activity-dependent changes in the neuromuscular transduction mechanisms contribute to neuromuscular fatigue; and 4) how the matching between the transduction mechanisms of motoneurons and those of their muscle fibers may help to optimize neuromuscular gradation efficiency and decrease the severity of fatigue. |
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Authors:
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D Kernell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 384 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1995 |
Date Detail:
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Created Date: 1996-03-19 Completed Date: 1996-03-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 135-45 Citation Subset: IM |
Affiliation:
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Department of Medical Physiology, University of Groningen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Motor Neurons / physiology* Muscle Fatigue / physiology* Muscle Fibers, Skeletal / physiology Neuromuscular Junction / physiology* |
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