Document Detail


Neuromuscular fatigue and exercise capacity in fibromyalgia syndrome.
MedLine Citation:
PMID:  22965792     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To assess quadriceps strength and fatigability by using femoral nerve magnetic stimulation (FNMS) and its relationship with exercise capacity in patients with fibromyalgia syndrome (FMS) and healthy controls. METHODS: 22 women (11 FMS, 11 controls) performed a maximal incremental cycling test and a quadriceps fatigue test on two separated visits. For quadriceps assessment, we used FNMS during and after maximum voluntary contraction (MVC) to evaluate central and peripheral factors of neuromuscular fatigue. Subjects performed sets of 10 intermittent (5-s on/5-s off) isometric contractions starting at 10% MVC, with 10% MVC increment from one set to another until exhaustion. Neuromuscular fatigue was assessed with FNMS after each set. RESULTS: FMS had reduced initial MVC compared to controls (102±18 versus 120±24 Nm, respectively; P<0.05) without significant impairment of voluntary activation (93.5±3.0 versus 93.1±3.4%; P<0.05). During the fatiguing task, FMS exhibited greater fall in evoked muscular responses (e.g. -26±6 versus -16±8% at set 50% MVC; P<0.05) but not in MVC (e.g. -24±7% versus -19±4% at set 50% MVC; P=0.12). During the cycling test, FMS had lowered maximal exercise capacity and enhanced rate of perceived exertion (RPE) compared to controls. Percentage reduction in evoked muscular responses during the quadriceps fatigue test correlated with maximal oxygen consumption (r=0.56; P<0.05) and RPE at submaximal intensity (r=0.84; P<0.05) during cycling. CONCLUSION: Larger impairment in muscle contractility is associated with enhanced perception of exertion and reduced maximal exercise capacity in FMS patients. Neuromuscular impairments should be considered as an important factor underlying functional limitations in FMS patients.
Authors:
Damien Bachasson; Michel Guinot; Bernard Wuyam; Anne Favre-Juvin; Guillaume Y Millet; Patrick Levy; Samuel Verges
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-10
Journal Detail:
Title:  Arthritis care & research     Volume:  -     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Affiliation:
Université Joseph Fourier, Laboratoire HP2, Grenoble, France; INSERM, U1042, Grenoble, France.
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