Document Detail

Neuromuscular electric stimulation enhances endothelial vascular control and hemodynamic function in paretic upper extremities of patients with stroke.
MedLine Citation:
PMID:  15241759     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effects of neuromuscular electric stimulation (NMES) on endothelial vascular control and hemodynamic function in patients in rehabilitation after acute stroke. DESIGN: Before-after trial. SETTING: Inpatients in a tertiary hospital. PARTICIPANTS: Sixteen stroke patients (11 women, 5 men) with a mean age of 60.6+/-19.5 years. INTERVENTIONS: All patients received NMES for paretic wrist extensor and flexor muscles 30 minutes daily, 5 days a week, for 4 weeks. The nonparetic upper extremities, which served as controls, did not receive NMES. MAIN OUTCOME MEASURES: Laser Doppler perfusion testing was conducted to measure cutaneous microcirculatory responses to transdermal iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), as specific endothelium-dependent and -independent vasodilators, respectively. Arterial and venous hemodynamic function was also measured by impedance plethysmography. RESULTS: Before NMES treatment, the venous capacity and compliance of the paretic extremities did not differ significantly from those of the nonparetic extremities. However, hyperemic arterial inflow, ACh-induced cutaneous perfusion, and the ratio of ACh- to SNP-induced cutaneous perfusion were lower in the paretic than in the nonparetic extremities. After NMES treatment, hyperemic arterial inflow and venous outflow increased by 21.5% and 57.2%, respectively, in the paretic extremities (P<.05). ACh-induced cutaneous perfusion and the ratio of ACh- to SNP-induced cutaneous perfusion were also significantly enhanced in the paretic extremities. In contrast, hyperemic arterial inflow decreased by 39.6% in the nonparetic extremities (P<.05), and endothelium-dependent cutaneous vasodilation also decreased significantly. CONCLUSIONS: NMES therapy may enhance the hyperemic arterial response and endothelium-dependent dilation in skin vasculature in the paretic upper extremities of patients with stroke.
Jong-Shyan Wang; Ssu-Yuan Chen; Ching Lan; May-Kuen Wong; Jin-Shin Lai
Related Documents :
1898419 - Vasoactive properties of procyanidins from hypericum perforatum l. in isolated porcine ...
20219129 - Patients with migraine with aura have increased flow mediated dilation.
7600649 - Bradykinin-induced vasodilation is impaired at the atherosclerotic site but is preserve...
6549149 - Characterization of the relaxant effects of vasoactive intestinal peptide (vip) and phi...
19114959 - Capsaicin blocks hiv protease inhibitor ritonavir-induced vascular dysfunction in porci...
7532439 - Endothelial modulation of vascular tone in isolated porcine and bovine basilar arteries.
10052489 - Sites of stenosis in av fistulae for haemodialysis access.
16440569 - Multidetector-row ct of renal arteries: review of the performances in normo- and hypert...
10731649 - Are pulmonary homografts which were subjected to pulmonary hypertension more appropriat...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  85     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-08     Completed Date:  2004-08-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1112-6     Citation Subset:  AIM; IM    
Graduate Institute of Rehabilitation Sciences and Center for Gerontological Research, Chang-Gung University, Tao-Yuan, Taipei, Taiwan 10016.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcholine / pharmacology
Cerebral Hemorrhage / rehabilitation
Cerebral Infarction / rehabilitation
Electric Stimulation Therapy*
Endothelium, Vascular / drug effects
Ferrous Compounds
Middle Aged
Nitroprusside / pharmacology
Paresis / rehabilitation*
Stroke / rehabilitation*
Upper Extremity
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Ferrous Compounds; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine; 7720-78-7/ferrous sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Robotic therapy for chronic motor impairments after stroke: Follow-up results.
Next Document:  Phenol block for cervical dystonia: effects and side effects.