Document Detail

Neuromuscular and cardiovascular effects of doxacurium in children anaesthetized with halothane.
MedLine Citation:
PMID:  2522789     Owner:  NLM     Status:  MEDLINE    
The neuromuscular and cardiovascular effects of doxacurium chloride (BW A938U) were evaluated in 27 children (2-12 yr) anaesthetized with 1% halothane and nitrous oxide in oxygen. In nine children the incremental technique was used to establish a cumulative dose-response curve by train-of-four stimulation. The remaining children received either 30 or 50 micrograms kg-1 of the drug as a single bolus. The median ED50 and ED95 of doxacurium in children were 19 and 32 micrograms kg-1, respectively. No clinically significant change in heart rate or arterial pressure occurred. Following doxacurium 30 micrograms kg-1 and 50 micrograms kg-1, recovery to 25% of control occurred in 25 (SEM 6) and 44 (3) min, respectively. The recovery index (25-75% of control) was 27 (2) min. The duration of action of doxacurium is similar to that of tubocurarine and dimethyl-tubocurarine in children. Compared with adults, children seem to require more doxacurium (microgram kg-1) to achieve a comparable degree of neuromuscular depression, and they recover more rapidly.
N G Goudsouzian; J K Alifimoff; L M Liu; V Foster; B McNulty; J J Savarese
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  62     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-05-24     Completed Date:  1989-05-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  263-8     Citation Subset:  IM    
Department of Anesthesia, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
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MeSH Terms
Anesthesia Recovery Period
Blood Pressure / drug effects
Child, Preschool
Dose-Response Relationship, Drug
Heart Rate / drug effects
Hemodynamics / drug effects*
Isoquinolines / adverse effects,  pharmacology*
Neuromuscular Junction / drug effects*
Neuromuscular Nondepolarizing Agents / adverse effects,  pharmacology*
Time Factors
Reg. No./Substance:
0/Isoquinolines; 0/Neuromuscular Nondepolarizing Agents; 106819-53-8/doxacurium; 151-67-7/Halothane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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