| Neuromuscular and cardiovascular effects of doxacurium in children anaesthetized with halothane. | |
| | |
MedLine Citation:
|
PMID: 2522789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The neuromuscular and cardiovascular effects of doxacurium chloride (BW A938U) were evaluated in 27 children (2-12 yr) anaesthetized with 1% halothane and nitrous oxide in oxygen. In nine children the incremental technique was used to establish a cumulative dose-response curve by train-of-four stimulation. The remaining children received either 30 or 50 micrograms kg-1 of the drug as a single bolus. The median ED50 and ED95 of doxacurium in children were 19 and 32 micrograms kg-1, respectively. No clinically significant change in heart rate or arterial pressure occurred. Following doxacurium 30 micrograms kg-1 and 50 micrograms kg-1, recovery to 25% of control occurred in 25 (SEM 6) and 44 (3) min, respectively. The recovery index (25-75% of control) was 27 (2) min. The duration of action of doxacurium is similar to that of tubocurarine and dimethyl-tubocurarine in children. Compared with adults, children seem to require more doxacurium (microgram kg-1) to achieve a comparable degree of neuromuscular depression, and they recover more rapidly. |
| | |
Authors:
|
N G Goudsouzian; J K Alifimoff; L M Liu; V Foster; B McNulty; J J Savarese |
Related Documents
:
|
19230769 - The use of virtual reality for needle-related procedural pain and distress in children ... 9584339 - The effects of a hospital staff training program on the treatment practices of postoper... 16507189 - Perioperative anxiety and postoperative behavioural disturbances in children: compariso... 8421649 - The effect of preparation for lumbar puncture on children undergoing chemotherapy. 10792749 - Sedation failures in children undergoing mri and ct: is temperament a factor? 9836209 - Sublingual midazolam premedication in children: a dose response study. 10813699 - Food consumption, activity, and overweight among elementary school children in an appal... 18366429 - Promoting broad and stable improvements in low-income children's numerical knowledge th... 19378209 - Stability of children with cerebral palsy in their wheelchair seating: perceptions of p... |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of anaesthesia Volume: 62 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1989 Mar |
Date Detail:
|
Created Date: 1989-05-24 Completed Date: 1989-05-24 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 263-8 Citation Subset: IM |
Affiliation:
|
Department of Anesthesia, Harvard Medical School, Massachusetts General Hospital, Boston 02114. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia Recovery Period Blood Pressure / drug effects Child Child, Preschool Dose-Response Relationship, Drug Halothane* Heart Rate / drug effects Hemodynamics / drug effects* Humans Isoquinolines / adverse effects, pharmacology* Neuromuscular Junction / drug effects* Neuromuscular Nondepolarizing Agents / adverse effects, pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Isoquinolines; 0/Neuromuscular Nondepolarizing Agents; 106819-53-8/doxacurium; 151-67-7/Halothane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coronary angioplasty and left ventricular function in single vessel coronary artery disease.
Next Document: Double burst stimulation (DBS): a new pattern of nerve stimulation to identify residual neuromuscula...