Document Detail

Neuromuscular and cardiovascular advantages of combinations of mivacurium and rocuronium over either drug alone.
MedLine Citation:
PMID:  8984866     Owner:  NLM     Status:  MEDLINE    
We investigated isobolic mixtures of mivacurium and rocuronium to determine if the combination offered any advantages over either drug alone. We used five dose regimens to achieve ED95 x 2: [(1.5 x ED95 mivacurium) + (0.5 x ED95 rocuronium); (1 x ED95 mivacurium) + (1 x ED95 rocuronium); (0.5 x ED95 mivacurium) + (1.5 x ED95 rocuronium); (2 x ED95 mivacurium); (2 x ED95 rocuronium)]. We studied onset time, duration of block, recovery of block, arterial blood pressure and heart rate. Mivacurium alone produced the block of shortest duration (p < 0.001). Onset time was shortest in the rocuronium alone group and was significantly faster in all the rocuronium treated groups compared to mivacurium alone (p < 0.001). Arterial blood pressure and heart rate decreased transiently in the mivacurium alone group but not in the other groups. These results demonstrate increased cardiovascular stability and more rapid onset of block with combinations of mivacurium and rocuronium without significant prolongation of the block.
S Y Kim; M H Cho
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  51     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-01-07     Completed Date:  1997-01-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  929-31     Citation Subset:  AIM; IM    
Department of Anaesthesiology, Soon Chun Hyang University and Hospital, Seoul, Korea.
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MeSH Terms
Androstanols / pharmacology*
Anesthesia, General
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Drug Interactions
Heart Rate / drug effects
Hemodynamics / drug effects*
Isoquinolines / pharmacology*
Middle Aged
Neuromuscular Junction / drug effects*
Neuromuscular Nondepolarizing Agents / pharmacology*
Time Factors
Reg. No./Substance:
0/Androstanols; 0/Isoquinolines; 0/Neuromuscular Nondepolarizing Agents; 106791-40-6/mivacurium; 143558-00-3/rocuronium
Comment In:
Anaesthesia. 1997 Mar;52(3):279-80   [PMID:  9124673 ]
Anaesthesia. 1997 Mar;52(3):280   [PMID:  9124674 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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