| Neuromuscular blockade with vecuronium in paediatric patients with burn injury. | |
| | |
MedLine Citation:
|
PMID: 2570602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. The effect of body surface area (BSA) burn injury on neuromuscular pharmacodynamics of vecuronium was evaluated. 2. The neuromuscular responses of 15 burned children were compared with those in five controls. 3. The effective dose for 50% suppression of twitch tension (ED50) was 34 micrograms kg-1 for patients with less than 40% BSA burn, 55 micrograms kg-1 for 40-60% BSA burn, and 65 micrograms kg-1 for patients with greater than 60% BSA burn. These values were significantly higher than the value for control patients, which was 18 micrograms kg-1. 4. Burn injury induces a resistance to the neuromuscular effects of vecuronium, the magnitude of which is related to burn size. |
| | |
Authors:
|
A K Mills; J A Martyn |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: British journal of clinical pharmacology Volume: 28 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1989 Aug |
Date Detail:
|
Created Date: 1989-10-23 Completed Date: 1989-10-23 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 155-9 Citation Subset: IM |
Affiliation:
|
Department of Anaesthesiology, Harvard Medical School, Boston, MA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Anesthesia Burns / physiopathology* Child Child, Preschool Dose-Response Relationship, Drug Electric Stimulation Female Humans Infant Male Muscle Contraction / drug effects Neuromuscular Blocking Agents* Vecuronium Bromide / administration & dosage, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
GM 31569/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Neuromuscular Blocking Agents; 50700-72-6/Vecuronium Bromide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of airways, tremor and chronotropic responses to inhaled salbutamol in the quantification...
Next Document: The effect of roxatidine acetate and cimetidine on hepatic drug clearance assessed by simultaneous a...