| Neuromuscular block with vecuronium reduces the rapidly extracted auditory evoked potentials index during steady state anesthesia. | |
| | |
MedLine Citation:
|
PMID: 14656779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: During clinical monitoring, vecuronium appeared to reduce the rapidly extracted auditory evoked potentials index (A-line ARX index or AAI) to some extent. A prospective and randomized study was designed to analyze this phenomenon. METHODS: Forty adult patients undergoing elective surgery were studied. After tracheal intubation, anesthesia was maintained with an end-tidal isoflurane concentration (F(ET)ISO) of 1.0% for 20 min, then a 10-mL dose of either vecuronium 0.05 mg*kg(-1), 0.1 mg*kg(-1), 0.2 mg*kg(-1) or saline was administered in a randomized, double-blind design. The AAI and bispectral index (BI(hx)) were monitored throughout the study and analyzed off-line. RESULTS: BI(hx) was unaltered after the administration of saline or vecuronium. The mean of the averaged (per patient) AAI values recorded from two minutes to ten minutes after the administration of saline or vecuronium 0.05 mg*kg(-1) did not differ significantly from the corresponding mean recorded from 15 min to 20 min after F(ET)ISO maintained 1.0% (P = 0.678, 0.169), however after the administration of vecuronium 0.1 mg*kg(-1) or 0.2 mg*kg(-1), AAI was reduced from 18.3, 18.0 to 14.8, 13.4 (P = 0.016, 0.017). CONCLUSIONS: Neuromuscular block with vecuronium reduces AAI in patients during steady state anesthesia without surgical stimuli, while BI(hx) is unaltered. The cut-off values of AAI for events should be determined according to the level of neuromuscular blockade when monitoring the depth of anesthesia/sedation. |
| | |
Authors:
|
Sheng-Jin Ge; Xin-Liang Zhuang; Ri-Hui He; Ying-Tian Wang; Xi Zhang; Shi-Wei Huang |
Related Documents
:
|
10472219 - Influence of metoclopramide on plasma cholinesterase and duration of action of mivacurium. 6536519 - Age influences the minimum infusion rate (ed50) for continuous infusions of althesin an... 3549029 - Double-blind comparison of lidocaine, tubocurarine and diazepam pretreatment in modifyi... 3936529 - Effects of alfentanil on cerebral vascular reactivity in dogs. 12707129 - Remifentanil with thiopental for tracheal intubation without muscle relaxants. 278459 - Halothane anaesthesia and suxamethonium iii. atropine 30 s before a second dose of suxa... 19729969 - Clinical assessment of tacrolimus therapy in lupus nephritis: one-year follow-up study ... 769949 - Cyclophosphamide (nsc-26271) maintenance therapy after a second remission of childhood ... 16789799 - Eletriptan: a review of its use in the acute treatment of migraine. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Canadian journal of anaesthesia = Journal canadien d'anesthésie Volume: 50 ISSN: 0832-610X ISO Abbreviation: Can J Anaesth Publication Date: 2003 Dec |
Date Detail:
|
Created Date: 2003-12-05 Completed Date: 2004-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8701709 Medline TA: Can J Anaesth Country: Canada |
Other Details:
|
Languages: eng Pagination: 1017-22 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, Shanghai Jiaotong University Affiliated Shanghai First People'Hospital, Shanghai, China. steeroncn@yahoo.com.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anesthesia, General* Electroencephalography Evoked Potentials, Auditory / drug effects* Female Humans Male Middle Aged Neuromuscular Blockade / methods* Neuromuscular Nondepolarizing Agents / administration & dosage, pharmacology* Prospective Studies Signal Processing, Computer-Assisted Vecuronium Bromide / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Neuromuscular Nondepolarizing Agents; 50700-72-6/Vecuronium Bromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Volume replacement with HES 130/0.4 may reduce the inflammatory response in patients undergoing majo...
Next Document: Prophylactic iv ondansetron reduces nausea, vomiting and pruritus following epidural morphine for po...