Document Detail


Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2.
MedLine Citation:
PMID:  21856425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The function of endogenous interleukin-1β (IL-1β) signaling in acute seizure activity was examined using transgenic mice harboring targeted deletions in the genes for either IL-1β (Il1b) or its signaling receptor (Il1r1). Acute epileptic seizure activity was modeled using two mechanistically distinct chemoconvulsants, kainic acid (KA) and pentylenetetrazole (PTZ). KA-induced seizure activity was more severe in homozygous null (-/-) Il1b mice compared to their wild-type (+/+) littermate controls, as indicated by an increase in the incidence of sustained generalized convulsive seizure activity. In the PTZ seizure model, the incidence of acute convulsive seizures was increased in both Il1b and Il1r1-/- mice compared to their respective +/+ littermate controls. Interestingly, the selective cyclooxygenase (COX)-2 inhibitor, rofecoxib, mimicked the effect of IL-1β deficiency on PTZ-induced convulsions in Il1r1+/+ but not -/- mice. Together, these results suggest that endogenous IL-1β possesses anticonvulsive properties that may be mediated by arachidonic acid metabolites derived from the catalytic action of COX-2.
Authors:
Robert J Claycomb; Sandra J Hewett; James A Hewett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-10
Journal Detail:
Title:  Neurobiology of disease     Volume:  45     ISSN:  1095-953X     ISO Abbreviation:  Neurobiol. Dis.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-07-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9500169     Medline TA:  Neurobiol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  234-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cyclooxygenase 2 / metabolism*
Cyclooxygenase Inhibitors / pharmacology
Interleukin-1beta / genetics,  metabolism*
Kainic Acid
Lactones / pharmacology
Mice
Mice, Knockout
Pentylenetetrazole
Receptors, Interleukin-1 / genetics,  metabolism
Seizures / chemically induced,  genetics,  metabolism*
Sulfones / pharmacology
Grant Support
ID/Acronym/Agency:
NS036812/NS/NINDS NIH HHS; NS051445/NS/NINDS NIH HHS; NS056304/NS/NINDS NIH HHS; R01 NS036812/NS/NINDS NIH HHS; R01 NS036812-14/NS/NINDS NIH HHS; R01 NS051445-04/NS/NINDS NIH HHS; R21 NS056304-02/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Interleukin-1beta; 0/Lactones; 0/Receptors, Interleukin-1; 0/Sulfones; 0/rofecoxib; 487-79-6/Kainic Acid; 54-95-5/Pentylenetetrazole; EC 1.14.99.1/Cyclooxygenase 2
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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