| Neuromodulatory mechanism underlying the effect of the atypical dipeptide neuroleptic dilept. | |
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MedLine Citation:
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PMID: 14968162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effects of a new dipeptide neuroleptic Dilept (N-caproyl-L-prolyl-L-tyrosine methyl ester) on activity of neurotransmitter systems in the brain. Dilept possessed antidopamine, glutamate modulatory, and cholinomimetic properties. These data indicate that Dilept is of potential efficacy in relieving positive and negative symptoms of schizophrenia. |
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Authors:
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M V Retyunskaya; L S Guzevatykh; N A Bondarenko; T A Gudasheva; R U Ostrovskaya; T A Voronina |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 136 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2004-02-17 Completed Date: 2004-08-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 467-70 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology, Russian Academy of Medical Sciences. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipsychotic Agents / pharmacology* Apomorphine / pharmacology Avoidance Learning / drug effects Behavior, Animal / drug effects Brain / drug effects, metabolism Ketamine / pharmacology Male Mice Mice, Inbred C57BL Neurotransmitter Agents / metabolism* Proline / analogs & derivatives*, pharmacology* Schizophrenia / drug therapy, metabolism Tyrosine / analogs & derivatives*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/GZR 123; 0/Neurotransmitter Agents; 147-85-3/Proline; 55520-40-6/Tyrosine; 58-00-4/Apomorphine; 6740-88-1/Ketamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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