Document Detail

Neuromodulatory mechanism underlying the effect of the atypical dipeptide neuroleptic dilept.
MedLine Citation:
PMID:  14968162     Owner:  NLM     Status:  MEDLINE    
We studied the effects of a new dipeptide neuroleptic Dilept (N-caproyl-L-prolyl-L-tyrosine methyl ester) on activity of neurotransmitter systems in the brain. Dilept possessed antidopamine, glutamate modulatory, and cholinomimetic properties. These data indicate that Dilept is of potential efficacy in relieving positive and negative symptoms of schizophrenia.
M V Retyunskaya; L S Guzevatykh; N A Bondarenko; T A Gudasheva; R U Ostrovskaya; T A Voronina
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  136     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2004-02-17     Completed Date:  2004-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  467-70     Citation Subset:  IM    
Institute of Pharmacology, Russian Academy of Medical Sciences.
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MeSH Terms
Antipsychotic Agents / pharmacology*
Apomorphine / pharmacology
Avoidance Learning / drug effects
Behavior, Animal / drug effects
Brain / drug effects,  metabolism
Ketamine / pharmacology
Mice, Inbred C57BL
Neurotransmitter Agents / metabolism*
Proline / analogs & derivatives*,  pharmacology*
Schizophrenia / drug therapy,  metabolism
Tyrosine / analogs & derivatives*,  pharmacology*
Reg. No./Substance:
0/Antipsychotic Agents; 0/GZR 123; 0/Neurotransmitter Agents; 147-85-3/Proline; 55520-40-6/Tyrosine; 58-00-4/Apomorphine; 6740-88-1/Ketamine

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