| Neuromodulators and hypoxic hypothermia in the rat. | |
| | |
MedLine Citation:
|
PMID: 9749954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study was designed to assess if opioids or adenosine are involved in the hypometabolism induced by hypoxia in the rat. Accordingly, antagonists such as naloxone (NLX) for opioids or theophylline (THEO) for adenosine were injected into conscious adult rats acutely exposed to either ambient hypoxia (AHx, FIO2: 12%) at ambient temperatures of 26 or 9 degrees C, or to CO hypoxia (COHx, FICO = 0.05%) at an ambient temperature (Ta) of 9 degrees C. Oxygen consumption, ventilation, colonic temperature and shivering were recorded. The results show that with NLX, the degree of hypoxic hypometabolism was reduced with AHx at 26 degrees C and slightly decreased with COHx at 9 degrees C. With THEO, hypoxic hypometabolism was slightly reduced with AHx and COHx at 9 degrees C. The ventilatory response to AHx and COHx was not consistently affected by either NLX or THEO. It is concluded that adenosine and opioids play a minor role, in mediating AHx or COHx hypothermia, especially during cold exposure. |
| | |
Authors:
|
H Gautier; C Murariu |
Related Documents
:
|
8899934 - Are physiological effects of sleep deprivation in the rat mediated by bacterial invasion? 233774 - Tissue metabolism and enzyme activities in the rodent heterocephalus glaber, a poor tem... 1583464 - Behavioral thermoregulation by hypoxic rats. 8510794 - Fever and feeding: differential actions of macrophage inflammatory protein-1 (mip-1), m... 10662734 - Superoxide anion curbs nitric oxide modulation of afferent arteriolar ang ii responsive... 9468194 - Connexin45 expression is preferentially associated with the ventricular conduction syst... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Respiration physiology Volume: 112 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1998 Jun |
Date Detail:
|
Created Date: 1998-12-09 Completed Date: 1998-12-09 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 315-24 Citation Subset: IM; S |
Affiliation:
|
Atelier de Physiologie Respiratoire, Faculté de Médecine Saint-Antoine, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine
/
physiology Animals Anoxia / metabolism, physiopathology* Body Temperature / physiology Carbon Monoxide / toxicity Hypothermia / metabolism, physiopathology* Male Naloxone / pharmacology Narcotic Antagonists / pharmacology Neurotransmitter Agents / physiology* Oxygen Consumption / drug effects Phosphodiesterase Inhibitors / pharmacology Rats Rats, Wistar Theophylline / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Narcotic Antagonists; 0/Neurotransmitter Agents; 0/Phosphodiesterase Inhibitors; 465-65-6/Naloxone; 58-55-9/Theophylline; 58-61-7/Adenosine; 630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High-frequency oscillation and centroid frequency of diaphragm EMG during inspiratory loading.
Next Document: Morphometric analysis of postnatal lung development in the tammar wallaby: light microscopy.