| Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction. | |
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MedLine Citation:
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PMID: 11721098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microdialysis is a means of measuring neurochemical changes in the extracellular space and has been applied in acute brain trauma, subarachnoid hemorrhage and stroke patients. In this study, we monitored neurochemical changes in the extracellular space using microdialysis in a patient with left-sided hemispheric infarction treated with moderate hypothermia (33 degrees C). Microdialysis probes were obtained from the infarcted and noninfarcted hemisphere during hypothermia and rewarming. Concentrations of extracellular substances in the infarcted hemisphere (glutamate, glycerine, lactate/pyruvate) decreased with hypothermia and remained stable (glutamate) or increased (glycerine, lactate/pyruvate) during rewarming. Concentrations of these substances in the noninfarcted hemisphere remained at normal levels. Microdialysis monitoring of therapeutic hypothermia in severe hemispheric infarction might be a useful additional monitoring tool to assess the status of the brain and to predict further deterioration. |
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Authors:
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W R Schäbitz; C Berger; P D Schellinger; A Aschoff; T Steiner; S Schwab |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cerebrovascular diseases (Basel, Switzerland) Volume: 12 ISSN: 1015-9770 ISO Abbreviation: Cerebrovasc. Dis. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-11-26 Completed Date: 2002-02-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100851 Medline TA: Cerebrovasc Dis Country: Switzerland |
Other Details:
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Languages: eng Pagination: 298-302 Citation Subset: IM |
Copyright Information:
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Copyright 2001 S. Karger AG, Basel |
Affiliation:
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Department of Neurology, University of Heidelberg Medical School, Heidelberg, Germany. wolf_schaebitz@med.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Ischemia / metabolism, therapy Extracellular Space / metabolism Glutamic Acid / metabolism Glycerol / metabolism Humans Hypothermia, Induced* Infarction, Middle Cerebral Artery / metabolism*, radiography, therapy* Lactic Acid / metabolism Microdialysis Pyruvic Acid / metabolism Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 56-81-5/Glycerol; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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