| Neuromedin U--a study of its distribution in the rat. | |
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MedLine Citation:
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PMID: 3432125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of neuromedin U, a novel peptide originally isolated from porcine spinal cord, was investigated in the rat using a recently developed radioimmunoassay. High concentrations of neuromedin U-like immunoreactivity were found in the pituitary gland and gastrointestinal tract. Significant concentrations of immunoreactivity were also found in several regions of the rat brain, spinal cord and both male and female genitourinary tracts. In the small intestine, neuromedin U-like immunoreactivity was restricted to the submucosal muscular layers, suggesting localization in neurones rather than in epithelial cells. Chromatographic analysis of pituitary, spinal cord and gut revealed a single peak of immunoreactivity which did not co-elute with either synthetic porcine neuromedin U-25 nor neuromedin U-8, indicating inter-species molecular heterogeneity. |
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Authors:
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J Domin; M A Ghatei; P Chohan; S R Bloom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Peptides Volume: 8 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1987 Sep-Oct |
Date Detail:
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Created Date: 1988-03-02 Completed Date: 1988-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 779-84 Citation Subset: IM |
Affiliation:
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Department of Medicine, Royal Postgraduate Medical School, HammersmithHospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Chemistry* Digestive System / analysis* Female Male Neuropeptides / analysis* Pituitary Gland / analysis* Rats Rats, Inbred Strains Spinal Cord / analysis* Tissue Distribution Urogenital System / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 98530-27-9/neuromedin U 8; 98530-28-0/neuromedin U 25 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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