Document Detail

Neuromedin S: discovery and functions.
MedLine Citation:
PMID:  18214396     Owner:  NLM     Status:  MEDLINE    
Neuromedin S, a novel neuropeptide of 36 amino acids, was isolated from rat brain as an endogenous ligand for the orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, identified to date as type-1 and type-2 neuromedin U (NMU) receptors, respectively. The peptide was designated neuromedin S (NMS) because it is specifically expressed in the suprachiasmatic nucleus of the hypothalamus. NMS is structurally related to NMU; these peptides share a C-terminal core structure. In this review, we will outline the recent discoveries regarding the structure, cognate receptors, distribution, and possible physiological functions of NMS.
Kenji Mori; Mikiya Miyazato; Kenji Kangawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Results and problems in cell differentiation     Volume:  46     ISSN:  0080-1844     ISO Abbreviation:  Results Probl Cell Differ     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173555     Medline TA:  Results Probl Cell Differ     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  201-12     Citation Subset:  IM    
Department of Biochemistry, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka, Japan.
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MeSH Terms
Amino Acid Sequence
Circadian Rhythm
Hypothalamus / metabolism
Models, Biological
Molecular Sequence Data
Neuropeptides / chemistry*,  physiology*
Peptides / chemistry
Protein Binding
Sequence Homology, Amino Acid
Reg. No./Substance:
0/Ligands; 0/Neuropeptides; 0/Peptides; 0/neuromedin S; 117505-80-3/neuromedin U

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