Document Detail

Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia.
MedLine Citation:
PMID:  17614262     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To examine the relationship between the severity of neurological soft signs at onset and at the 1-year follow-up of patients with schizophrenia, and to investigate temporal stability of neurological soft signs within 1year from the onset of the first episode schizophrenia. METHODS: The study included 92 first-episode male schizophrenic patients. Neurological soft signs were assessed on the Neurological Evaluation Scale (NES) during index hospitalization and at a 1-year follow-up. The patients were divided into remitters and non-remitters according to their psychiatric status assessed at the 1-year follow-up, using the Positive and Negative Syndrome Scale (PANSS). RESULTS: A trend for a lower score for the NES item "others" in late remitters versus non-remitters at baseline was found during index hospitalization. At the 1-year follow-up, the overall severity of the neurological soft signs was statistically significantly higher in non-remitters than in remitters. Within 1year after index hospitalization, a significant reduction of neurological soft signs, with the exception of sensory integration, occurred in remitters. Within 1year after index hospitalization, the non-remitters reported a significant reduction of the overall NES score. CONCLUSION: These findings in a population of patients with first episode schizophrenia are in accord with the findings of previous studies which found an association between neurological soft signs, treatment response and outcome. This association may characterize a subgroup of patients with a poor course of illness and outcome. Neurological soft signs might be regarded as one of the indicators of treatment outcome in patients suffering from their first episode of schizophrenia.
Radovan Prikryl; Eva Ceskova; Tomas Kasparek; Hana Kucerova
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-05
Journal Detail:
Title:  European psychiatry : the journal of the Association of European Psychiatrists     Volume:  22     ISSN:  0924-9338     ISO Abbreviation:  Eur. Psychiatry     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111820     Medline TA:  Eur Psychiatry     Country:  France    
Other Details:
Languages:  eng     Pagination:  499-504     Citation Subset:  IM    
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital, Jihlavska 20, 625 00 Brno, Czech Republic.
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MeSH Terms
Antipsychotic Agents / therapeutic use
Follow-Up Studies
Nervous System Diseases / diagnosis*
Neurologic Examination* / drug effects
Outcome Assessment (Health Care)
Psychiatric Status Rating Scales
Schizophrenia / diagnosis*
Schizophrenic Psychology*
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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