Document Detail

Neurological soft signs and schizotypal dimensions in unaffected siblings of patients with schizophrenia.
MedLine Citation:
PMID:  19959242     Owner:  NLM     Status:  MEDLINE    
The objectives were to determine the neurological soft signs (NSS) scores in unaffected siblings of patients with schizophrenia compared with healthy controls and to examine their relationships with schizotypal dimensions. Participants comprised 31 unaffected siblings of patients with schizophrenia and 60 healthy controls matched according to age, gender and school level who were assessed by the Schizotypal Personality Questionnaire (SPQ) and the Krebs et al. NSS Scale. Higher NSS total scores and sub-scores were found in the unaffected siblings compared with the controls. The SPQ total score was significantly higher in unaffected siblings compared with control subjects. The NSS total score was positively correlated with the SPQ total score and the SPQ disorganization sub-score in unaffected siblings of patients with schizophrenia. Additionally, in unaffected siblings, motor coordination and integration abnormalities were positively correlated with the SPQ total score and the cognitive-perceptual sub-score. Motor integration abnormalities were also correlated with the SPQ disorganization sub-score. These results reveal that NSS, especially motor signs, are associated with some schizotypal dimensions in siblings of patients with schizophrenia, suggesting the value of using both assessments to study high risk populations.
Anwar Mechri; Leila Gassab; H?la Slama; Lotfi Gaha; Mohamed Saoud; Marie Odile Krebs
Publication Detail:
Type:  Journal Article     Date:  2009-12-02
Journal Detail:
Title:  Psychiatry research     Volume:  175     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  IM    
Research Laboratory Vulnerability to psychotic disorders, University of Monastir, Tunisia.
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MeSH Terms
Case-Control Studies
Middle Aged
Neuropsychological Tests
Personality Inventory
Psychomotor Performance / physiology
Schizophrenia / complications*
Schizophrenic Psychology*
Schizotypal Personality Disorder / diagnosis*,  genetics*
Siblings / psychology*
Statistics, Nonparametric
Young Adult

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