Document Detail


Neurological soft signs in non-psychotic patients with cannabis dependence.
MedLine Citation:
PMID:  21054691     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Psychomotor performance has consistently been found to be altered in chronic cannabis users. Neurological soft signs (NSS) reflect neurological dysfunction involving integrative networks, especially those involving the cerebellum, where cannabinoid receptors are particularly concentrated. Our objective was to study, for the first time, NSS in a group of patients with cannabis dependence compared with a of healthy control subjects, matched for age, gender and level of education. All outpatients seeking treatment for chronic cannabis use in the substance abuse department of Sainte-Anne Hospital in Paris between June 2007 and May 2009 and meeting the cannabis dependence DSM-IV criteria were included in the study (n = 45). Patients with psychotic disorders, bipolar 1 disorder and current alcohol, opioid or cocaine dependence were excluded. All patients and controls were assessed using the Diagnostic Interview for Genetic Studies, which screens for lifetime DSM-IV diagnoses, and the Standardized Neurological Examination of Neurological Soft Signs. NSS scores were significantly higher in patients with cannabis dependence compared with healthy subjects (8.90 ± 4.85 versus 6.71 ± 2.73, respectively, Mann-Whitney: U = 775.0, P = 0.05). Patients had particularly high scores on motor coordination and sensory integration NSS factors. Cannabis dependence is associated with more NSS and especially motor coordination and sensory integration signs. These results suggest that cannabinoids interact with the brain networks underlying NSS, known to be altered in schizophrenia.
Authors:
Alain Dervaux; Marie-Chantal Bourdel; Xavier Laqueille; Marie-Odile Krebs
Publication Detail:
Type:  Journal Article     Date:  2010-11-04
Journal Detail:
Title:  Addiction biology     Volume:  18     ISSN:  1369-1600     ISO Abbreviation:  Addict Biol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9604935     Medline TA:  Addict Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-21     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors, Addiction Biology © 2010 Society for the Study of Addiction.
Affiliation:
Service d'Addictologie, Centre Hospitalier Sainte-Anne, France INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre Psychiatrie et Neurosciences, U894, France Université Paris Descartes, Faculté de Médecine Paris Descartes, Service Hospitalo Universitaire, Centre Hospitalier Sainte-Anne, France.
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