| Neurological paraneoplastic syndromes in patients with small cell lung cancer. A prospective survey of 150 patients. | |
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MedLine Citation:
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PMID: 1659614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One hundred and fifty patients presenting with small cell lung cancer (SCLC) to chest physicians, were assessed neurologically. Neuromuscular or autonomic deficits were common and occurred in up to 44% of cases. Weakness, dry mouth, and weight loss were not mutually independent and may represent the syndrome formerly described as carcinomatous neuromyopathy. By contrast, undoubted paraneoplastic syndromes were much less commonly detected. Two patients had the Lambert-Eaton myasthenic syndrome (LEMS) and one had subacute sensory neuropathy (SSN). In these patients, neurological symptoms antedated other manifestations of cancer, by between six and 17 months. The 95% confidence interval for the prevalence of LEMS or SSN among SCLC patients was 0-4%, consistent with the results of previous retrospective or smaller studies: summing these, the overall prevalence of LEMS among SCLC patients is close to 3%, which implies about 250 new cases per annum in England and Wales. If LEMS and SSN are the least uncommon neurological paraneoplastic syndromes in SCLC patients, this may reflect the accessibility of motor nerve terminals and dorsal root ganglia to cross-reactive anti-tumour cell antibodies. |
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Authors:
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G M Elrington; N M Murray; S G Spiro; J Newsom-Davis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 54 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1991-12-31 Completed Date: 1991-12-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 764-7 Citation Subset: IM |
Affiliation:
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National Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Small Cell
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diagnosis*,
physiopathology Female Ganglia, Spinal / physiopathology Humans Lambert-Eaton Myasthenic Syndrome / diagnosis, physiopathology Lung Neoplasms / diagnosis*, physiopathology Male Middle Aged Motor Neurons / physiology Nervous System / physiopathology Nervous System Diseases / diagnosis*, physiopathology Neurologic Examination Neuromuscular Diseases / diagnosis*, physiopathology Paraneoplastic Syndromes / diagnosis*, physiopathology Prospective Studies Sensation / physiology Synaptic Transmission / physiology* |
| Comments/Corrections | |
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