Document Detail

Neurological outcome in twins.
MedLine Citation:
PMID:  12234746     Owner:  NLM     Status:  MEDLINE    
Twins are at greater risk of death and severe morbidity than singletons which is in excess of that attributable to their greater prematurity. Monozygous, specifically monochorionic, twins are at greater risk than dichorionic twins. The major morbidity is neurological impairment usually presenting as cerebral palsy or severe learning disability and frequently, but not always, associated with fetal death of a co-twin. The likely pathogenesis of the neurological impairment is ischaemia attributable to haemodynamic imbalance via placental vascular anastomoses. In addition to the neurological impairment, congenital cardiac, renal, intestinal and other anomalies are more common but discordant in monozygous twins. It has been hypothesized that cerebral palsy and other neurological impairment in apparently singleton infants is attributable to early loss of a twin, the 'vanishing' twin phenomenon. It is also postulated that other congenital anomalies in singletons may be attributable to the same phenomenon.
P O D Pharoah
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  7     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-09-17     Completed Date:  2002-12-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM    
Department of Public Health, Muspratt Building, University of Liverpool, Liverpool, L69 3GB, UK.
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MeSH Terms
Cerebral Palsy* / epidemiology,  physiopathology
Congenital Abnormalities
Developmental Disabilities
Diseases in Twins* / epidemiology
Infant, Newborn
Nervous System Diseases* / epidemiology,  physiopathology

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